Matches in SemOpenAlex for { <https://semopenalex.org/work/W4386156797> ?p ?o ?g. }
- W4386156797 abstract "Shelterin and nucleosomes are the key players that organize mammalian chromosome ends into the protective telomere caps. However, how they interact with each other at telomeres remains unknown. We report cryo–electron microscopy structures of a human telomeric nucleosome both unbound and bound to the shelterin factor TRF1. Our structures reveal that TRF1 binds unwrapped nucleosomal DNA ends by engaging both the nucleosomal DNA and the histone octamer. Unexpectedly, TRF1 binding shifts the register of the nucleosomal DNA by 1 bp. We discovered that phosphorylation of the TRF1 C terminus and a noncanomical DNA binding surface on TRF1 are critical for its association with telomeric nucleosomes. These insights into shelterin-chromatin interactions have crucial implications for understanding telomeric chromatin organization and other roles of shelterin at telomeres including replication and transcription." @default.
- W4386156797 created "2023-08-26" @default.
- W4386156797 creator A5002216393 @default.
- W4386156797 creator A5002648229 @default.
- W4386156797 creator A5003402066 @default.
- W4386156797 creator A5030248116 @default.
- W4386156797 creator A5045925581 @default.
- W4386156797 creator A5058656286 @default.
- W4386156797 creator A5083404929 @default.
- W4386156797 creator A5084843841 @default.
- W4386156797 date "2023-08-25" @default.
- W4386156797 modified "2023-09-27" @default.
- W4386156797 title "Structural basis of telomeric nucleosome recognition by shelterin factor TRF1" @default.
- W4386156797 cites W1514480115 @default.
- W4386156797 cites W1871829615 @default.
- W4386156797 cites W1965063898 @default.
- W4386156797 cites W1974732946 @default.
- W4386156797 cites W1979389466 @default.
- W4386156797 cites W1981936717 @default.
- W4386156797 cites W1987384318 @default.
- W4386156797 cites W1998163656 @default.
- W4386156797 cites W2001467037 @default.
- W4386156797 cites W2007550555 @default.
- W4386156797 cites W2014496495 @default.
- W4386156797 cites W2028147887 @default.
- W4386156797 cites W2033731825 @default.
- W4386156797 cites W2047170452 @default.
- W4386156797 cites W2047832668 @default.
- W4386156797 cites W2048001067 @default.
- W4386156797 cites W2054770020 @default.
- W4386156797 cites W2068972095 @default.
- W4386156797 cites W2087011288 @default.
- W4386156797 cites W2089716206 @default.
- W4386156797 cites W2097604487 @default.
- W4386156797 cites W2101994612 @default.
- W4386156797 cites W2125724353 @default.
- W4386156797 cites W2127322768 @default.
- W4386156797 cites W2127440297 @default.
- W4386156797 cites W2132629607 @default.
- W4386156797 cites W2139940280 @default.
- W4386156797 cites W2145952889 @default.
- W4386156797 cites W2148226789 @default.
- W4386156797 cites W2152460540 @default.
- W4386156797 cites W2152562710 @default.
- W4386156797 cites W2154197653 @default.
- W4386156797 cites W2155983703 @default.
- W4386156797 cites W2159211495 @default.
- W4386156797 cites W2161232591 @default.
- W4386156797 cites W2165322854 @default.
- W4386156797 cites W2168974130 @default.
- W4386156797 cites W2321647501 @default.
- W4386156797 cites W2334348545 @default.
- W4386156797 cites W2336332472 @default.
- W4386156797 cites W2344664973 @default.
- W4386156797 cites W2427061751 @default.
- W4386156797 cites W2487704570 @default.
- W4386156797 cites W2585302695 @default.
- W4386156797 cites W2587625522 @default.
- W4386156797 cites W2610586915 @default.
- W4386156797 cites W2728385286 @default.
- W4386156797 cites W2734356283 @default.
- W4386156797 cites W2765322245 @default.
- W4386156797 cites W2797631238 @default.
- W4386156797 cites W2800336448 @default.
- W4386156797 cites W2892224724 @default.
- W4386156797 cites W2899714098 @default.
- W4386156797 cites W2953320394 @default.
- W4386156797 cites W2969960851 @default.
- W4386156797 cites W2973457155 @default.
- W4386156797 cites W2985720349 @default.
- W4386156797 cites W3005655837 @default.
- W4386156797 cites W3019281170 @default.
- W4386156797 cites W3021011563 @default.
- W4386156797 cites W3103292928 @default.
- W4386156797 cites W3108495343 @default.
- W4386156797 cites W3115301926 @default.
- W4386156797 cites W3127394761 @default.
- W4386156797 cites W3155018287 @default.
- W4386156797 cites W3213779066 @default.
- W4386156797 cites W4213190051 @default.
- W4386156797 cites W4214776784 @default.
- W4386156797 cites W4283331244 @default.
- W4386156797 cites W4288036107 @default.
- W4386156797 cites W4295679026 @default.
- W4386156797 cites W4295763006 @default.
- W4386156797 cites W4304974619 @default.
- W4386156797 cites W4310775336 @default.
- W4386156797 doi "https://doi.org/10.1126/sciadv.adi4148" @default.
- W4386156797 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37624885" @default.
- W4386156797 hasPublicationYear "2023" @default.
- W4386156797 type Work @default.
- W4386156797 citedByCount "0" @default.
- W4386156797 crossrefType "journal-article" @default.
- W4386156797 hasAuthorship W4386156797A5002216393 @default.
- W4386156797 hasAuthorship W4386156797A5002648229 @default.
- W4386156797 hasAuthorship W4386156797A5003402066 @default.
- W4386156797 hasAuthorship W4386156797A5030248116 @default.
- W4386156797 hasAuthorship W4386156797A5045925581 @default.
- W4386156797 hasAuthorship W4386156797A5058656286 @default.
- W4386156797 hasAuthorship W4386156797A5083404929 @default.