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- W4386156908 abstract "Abstract Regulatory B cells (Bregs) are immunosuppressive cells that support immunological tolerance by the production of IL‐10, IL‐35, and TGF‐β. Bregs arise from different developmental stages in response to inflammatory stimuli. In that regard, mounting evidence points towards a direct influence of gut microbiota on mucosal B cell development, activation, and regulation in health and disease. While an increasing number of diseases are associated with alterations in gut microbiome (dysbiosis), little is known about the role of microbiota on Breg development and induction in neuroinflammatory disorders. Notably, gut‐originating, IL‐10‐ and IgA‐producing regulatory plasma cells have recently been demonstrated to egress from the gut to suppress inflammation in the CNS raising fundamental questions about the triggers and functions of mucosal‐originating Bregs in systemic inflammation. Advancing our understanding of Bregs in neuroinflammatory diseases could lead to novel therapeutic approaches. Here, we summarize the main aspects of Breg differentiation and functions and evidence about their involvement in neuroinflammatory diseases. Further, we highlight current data of gut‐originating Bregs and their microbial interactions and discuss future microbiota‐regulatory B cell‐targeted therapies in immune‐mediated diseases." @default.
- W4386156908 created "2023-08-26" @default.
- W4386156908 creator A5031133408 @default.
- W4386156908 creator A5050137130 @default.
- W4386156908 creator A5059147261 @default.
- W4386156908 creator A5089713450 @default.
- W4386156908 date "2023-10-09" @default.
- W4386156908 modified "2023-10-17" @default.
- W4386156908 title "Therapeutic targeting of gut‐originating regulatory B cells in neuroinflammatory diseases" @default.
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