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• W4386156986 abstract "Abstract People with HIV are at increased risk for depression, though the neurobiological mechanisms underlying this are unclear. In the last decade, there has been a substantial rise in interest in the contribution of (neuro)inflammation to depression, coupled with rapid advancements in the resolution and sensitivity of biomarker assays such as Luminex, single molecular array and newly developed positron emission tomography radioligands. Numerous pre-clinical and clinical studies have recently leveraged these next-generation immunoassays to identify biomarkers that may be associated with HIV and depression (separately), though few studies have explored these biomarkers in co-occurring HIV and depression. Using a systematic search, we detected 33 publications involving a cumulative N = 10 590 participants which tested for associations between depressive symptoms and 55 biomarkers of inflammation and related processes in participants living with HIV. Formal meta-analyses were not possible as statistical reporting in the field was highly variable; future studies must fully report test statistics and effect size estimates. The majority of included studies were carried out in the United States, with samples that were primarily older and primarily men. Substantial further work is necessary to diversify the geographical, age, and sex distribution of samples in the field. This review finds that alterations in concentrations of certain biomarkers of neuroinflammation (interleukin-6, tumour necrosis factor-α, neopterin) may influence the association between HIV and depression. Equally, the chemokines monocyte chemoattractant protein-1 (MCP-1) and interleukin-8 (IL-8) or the metabolic index kynurenine:tryptophan (Kyn:Trp), which have been the focus of several studies, do not appear to be associated with depressive symptoms amongst people living with HIV, as all (MCP-1) or most (IL-8 and Kyn:Trp) available studies of these biomarkers reported non-significant associations. We propose a biomarker-driven hypothesis of the neuroimmunometabolic mechanisms that may precipitate the increased risk of depression among people with HIV. Chronically activated microglia, which trigger key neuroinflammatory cascades shown to be upregulated in people with HIV, may be the central link connecting HIV infection in the central nervous system with depressive symptoms. Findings from this review may inform research design in future studies of HIV-associated depression and enable concerted efforts towards biomarker discovery." @default.
• W4386156986 created "2023-08-26" @default.
• W4386156986 creator A5038299596 @default.
• W4386156986 date "2023-01-01" @default.
• W4386156986 modified "2023-10-14" @default.
• W4386156986 title "Depression and HIV: a scoping review in search of neuroimmune biomarkers" @default.
• W4386156986 cites W1483881410 @default.
• W4386156986 cites W1544863932 @default.
• W4386156986 cites W1826495180 @default.
• W4386156986 cites W1915977580 @default.
• W4386156986 cites W1946546799 @default.
• W4386156986 cites W1977797184 @default.
• W4386156986 cites W1985718159 @default.
• W4386156986 cites W1992470868 @default.
• W4386156986 cites W1996241541 @default.
• W4386156986 cites W2004462939 @default.
• W4386156986 cites W2007138672 @default.
• W4386156986 cites W2008385485 @default.
• W4386156986 cites W2019956571 @default.
• W4386156986 cites W2026925430 @default.
• W4386156986 cites W2040649786 @default.
• W4386156986 cites W2053889157 @default.
• W4386156986 cites W2054221300 @default.
• W4386156986 cites W2069809946 @default.
• W4386156986 cites W2074026975 @default.
• W4386156986 cites W2076249077 @default.
• W4386156986 cites W2082293375 @default.
• W4386156986 cites W2086093735 @default.
• W4386156986 cites W2096908475 @default.
• W4386156986 cites W2115046127 @default.
• W4386156986 cites W2119230351 @default.
• W4386156986 cites W2123851781 @default.
• W4386156986 cites W2127198790 @default.
• W4386156986 cites W2146758523 @default.
• W4386156986 cites W2152958471 @default.
• W4386156986 cites W2163188298 @default.
• W4386156986 cites W2169236274 @default.
• W4386156986 cites W2170892587 @default.
• W4386156986 cites W2190014693 @default.
• W4386156986 cites W2238913909 @default.
• W4386156986 cites W2280064070 @default.
• W4386156986 cites W2283283372 @default.
• W4386156986 cites W2285857929 @default.
• W4386156986 cites W2309165118 @default.
• W4386156986 cites W2328226844 @default.
• W4386156986 cites W2392201426 @default.
• W4386156986 cites W2397970637 @default.
• W4386156986 cites W2478122494 @default.
• W4386156986 cites W2541174001 @default.
• W4386156986 cites W2546868026 @default.
• W4386156986 cites W2565022774 @default.
• W4386156986 cites W2567362164 @default.
• W4386156986 cites W2612080295 @default.
• W4386156986 cites W2623710472 @default.
• W4386156986 cites W2742488649 @default.
• W4386156986 cites W2743887053 @default.
• W4386156986 cites W2765091711 @default.
• W4386156986 cites W2781594566 @default.
• W4386156986 cites W2781993597 @default.
• W4386156986 cites W2792562842 @default.
• W4386156986 cites W2794645689 @default.
• W4386156986 cites W2807834396 @default.
• W4386156986 cites W2892401664 @default.
• W4386156986 cites W2899056981 @default.
• W4386156986 cites W2914589057 @default.
• W4386156986 cites W2921196922 @default.
• W4386156986 cites W2929883268 @default.
• W4386156986 cites W2947170763 @default.
• W4386156986 cites W2948129990 @default.
• W4386156986 cites W2953025937 @default.
• W4386156986 cites W2978795816 @default.
• W4386156986 cites W2981716810 @default.
• W4386156986 cites W2991305225 @default.
• W4386156986 cites W2998510790 @default.
• W4386156986 cites W2999216616 @default.
• W4386156986 cites W3004022566 @default.
• W4386156986 cites W3004994518 @default.
• W4386156986 cites W3008574613 @default.
• W4386156986 cites W3011920098 @default.
• W4386156986 cites W3015753252 @default.
• W4386156986 cites W3019236334 @default.
• W4386156986 cites W3036855663 @default.
• W4386156986 cites W3042372355 @default.
• W4386156986 cites W3043471544 @default.
• W4386156986 cites W3044840706 @default.
• W4386156986 cites W3049432389 @default.
• W4386156986 cites W3086161802 @default.
• W4386156986 cites W3087016663 @default.
• W4386156986 cites W3087167773 @default.
• W4386156986 cites W3095267303 @default.
• W4386156986 cites W3097436588 @default.
• W4386156986 cites W3100660218 @default.
• W4386156986 cites W3101711066 @default.
• W4386156986 cites W3109558850 @default.
• W4386156986 cites W3111679375 @default.
• W4386156986 cites W3120759217 @default.
• W4386156986 cites W3126235065 @default.
• W4386156986 cites W3130169122 @default.
• W4386156986 cites W3134497497 @default.
• W4386156986 cites W3169662381 @default.

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