Matches in SemOpenAlex for { <https://semopenalex.org/work/W4386157047> ?p ?o ?g. }
- W4386157047 abstract "Aberrant enhancer activation is a key mechanism driving oncogene expression in many cancers. While much is known about the regulation of larger chromosome domains in eukaryotes, the details of enhancer-promoter interactions remain poorly understood. Recent work suggests co-activators like BRD4 and Mediator have little impact on enhancer-promoter interactions. In leukemias controlled by the MLL-AF4 fusion protein, we use the ultra-high resolution technique Micro-Capture-C (MCC) to show that MLL-AF4 binding promotes broad, high-density regions of enhancer-promoter interactions at a subset of key targets. These enhancers are enriched for transcription elongation factors like PAF1C and FACT, and the loss of these factors abolishes enhancer-promoter contact. This work not only provides an additional model for how MLL-AF4 is able to drive high levels of transcription at key genes in leukemia but also suggests a more general model linking enhancer-promoter crosstalk and transcription elongation." @default.
- W4386157047 created "2023-08-26" @default.
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- W4386157047 date "2023-08-25" @default.
- W4386157047 modified "2023-10-06" @default.
- W4386157047 title "MLL-AF4 cooperates with PAF1 and FACT to drive high-density enhancer interactions in leukemia" @default.
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