Matches in SemOpenAlex for { <https://semopenalex.org/work/W4386157107> ?p ?o ?g. }
- W4386157107 endingPage "12644" @default.
- W4386157107 startingPage "12629" @default.
- W4386157107 abstract "18F-Fluorination of sensitive molecules is often challenging, but can be accomplished under suitably mild conditions using radiofluorinated prosthetic groups (PGs). Herein, 1-alkylamino-7-[18F]fluoro-8-azaisatoic anhydrides ([18F]AFAs) are introduced as versatile 18F-labeled building blocks that can be used as amine-reactive or “click chemistry” PGs. [18F]AFAs were efficiently prepared within 15 min by “on cartridge” radiolabeling of readily accessible trimethylammonium precursors. Conjugation with a range of amines afforded the corresponding 2-alkylamino-6-[18F]fluoronicotinamides in radiochemical conversions (RCCs) of 15–98%. In addition, radiolabeling of alkyne- or azide-functionalized precursors with azidopropyl- or propargyl-substituted [18F]AFAs using Cu-catalyzed click cycloaddition afforded the corresponding conjugates in RCCs of 44–88%. The practical utility of the PGs was confirmed by the preparation of three 18F-labeled PSMA ligands in radiochemical yields of 28–42%. Biological evaluation in rats demonstrated excellent in vivo stability of all three conjugates. In addition, one conjugate ([18F]JK-PSMA-15) showed favorable imaging properties for high-contrast visualization of small PSMA-positive lesions." @default.
- W4386157107 created "2023-08-26" @default.
- W4386157107 creator A5005099895 @default.
- W4386157107 creator A5011443786 @default.
- W4386157107 creator A5018477953 @default.
- W4386157107 creator A5030234706 @default.
- W4386157107 creator A5031145007 @default.
- W4386157107 creator A5058325456 @default.
- W4386157107 creator A5073759010 @default.
- W4386157107 creator A5076382838 @default.
- W4386157107 creator A5089065222 @default.
- W4386157107 date "2023-08-25" @default.
- W4386157107 modified "2023-09-23" @default.
- W4386157107 title "7-[<sup>18</sup>F]Fluoro-8-azaisatoic Anhydrides: Versatile Prosthetic Groups for the Preparation of PET Tracers" @default.
- W4386157107 cites W1655641620 @default.
- W4386157107 cites W1792778099 @default.
- W4386157107 cites W1969332759 @default.
- W4386157107 cites W1981502499 @default.
- W4386157107 cites W1991441790 @default.
- W4386157107 cites W1993314947 @default.
- W4386157107 cites W1996732617 @default.
- W4386157107 cites W2004977522 @default.
- W4386157107 cites W2011204935 @default.
- W4386157107 cites W2015546047 @default.
- W4386157107 cites W2033819744 @default.
- W4386157107 cites W2038578630 @default.
- W4386157107 cites W2039018753 @default.
- W4386157107 cites W2050466265 @default.
- W4386157107 cites W2080006760 @default.
- W4386157107 cites W2084090004 @default.
- W4386157107 cites W2089148358 @default.
- W4386157107 cites W2115920211 @default.
- W4386157107 cites W2120873855 @default.
- W4386157107 cites W2155421560 @default.
- W4386157107 cites W2166934187 @default.
- W4386157107 cites W2275825748 @default.
- W4386157107 cites W2323389052 @default.
- W4386157107 cites W2326639051 @default.
- W4386157107 cites W2511910875 @default.
- W4386157107 cites W2554535346 @default.
- W4386157107 cites W2592608913 @default.
- W4386157107 cites W2626772460 @default.
- W4386157107 cites W2734584386 @default.
- W4386157107 cites W2762021406 @default.
- W4386157107 cites W2793686514 @default.
- W4386157107 cites W2898690812 @default.
- W4386157107 cites W2949959868 @default.
- W4386157107 cites W2953916273 @default.
- W4386157107 cites W2964058935 @default.
- W4386157107 cites W2979605075 @default.
- W4386157107 cites W3047132415 @default.
- W4386157107 cites W3084114647 @default.
- W4386157107 cites W3103252610 @default.
- W4386157107 cites W3138442368 @default.
- W4386157107 cites W3174339659 @default.
- W4386157107 cites W4385605171 @default.
- W4386157107 doi "https://doi.org/10.1021/acs.jmedchem.3c01310" @default.
- W4386157107 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37625106" @default.
- W4386157107 hasPublicationYear "2023" @default.
- W4386157107 type Work @default.
- W4386157107 citedByCount "0" @default.
- W4386157107 crossrefType "journal-article" @default.
- W4386157107 hasAuthorship W4386157107A5005099895 @default.
- W4386157107 hasAuthorship W4386157107A5011443786 @default.
- W4386157107 hasAuthorship W4386157107A5018477953 @default.
- W4386157107 hasAuthorship W4386157107A5030234706 @default.
- W4386157107 hasAuthorship W4386157107A5031145007 @default.
- W4386157107 hasAuthorship W4386157107A5058325456 @default.
- W4386157107 hasAuthorship W4386157107A5073759010 @default.
- W4386157107 hasAuthorship W4386157107A5076382838 @default.
- W4386157107 hasAuthorship W4386157107A5089065222 @default.
- W4386157107 hasBestOaLocation W43861571071 @default.
- W4386157107 hasConcept C131779359 @default.
- W4386157107 hasConcept C134306372 @default.
- W4386157107 hasConcept C150903083 @default.
- W4386157107 hasConcept C161790260 @default.
- W4386157107 hasConcept C178790620 @default.
- W4386157107 hasConcept C185592680 @default.
- W4386157107 hasConcept C197336794 @default.
- W4386157107 hasConcept C207001950 @default.
- W4386157107 hasConcept C21951064 @default.
- W4386157107 hasConcept C2779012754 @default.
- W4386157107 hasConcept C2779664164 @default.
- W4386157107 hasConcept C2780437523 @default.
- W4386157107 hasConcept C33923547 @default.
- W4386157107 hasConcept C69610077 @default.
- W4386157107 hasConcept C86803240 @default.
- W4386157107 hasConceptScore W4386157107C131779359 @default.
- W4386157107 hasConceptScore W4386157107C134306372 @default.
- W4386157107 hasConceptScore W4386157107C150903083 @default.
- W4386157107 hasConceptScore W4386157107C161790260 @default.
- W4386157107 hasConceptScore W4386157107C178790620 @default.
- W4386157107 hasConceptScore W4386157107C185592680 @default.
- W4386157107 hasConceptScore W4386157107C197336794 @default.
- W4386157107 hasConceptScore W4386157107C207001950 @default.
- W4386157107 hasConceptScore W4386157107C21951064 @default.
- W4386157107 hasConceptScore W4386157107C2779012754 @default.
- W4386157107 hasConceptScore W4386157107C2779664164 @default.