FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4386157352> ?p ?o ?g. }

• W4386157352 endingPage "184219" @default.
• W4386157352 startingPage "184219" @default.
• W4386157352 abstract "Extracellular Vesicles (EVs) are nanosized vesicles derived from all cell types. EV cargo allows for intercellular communication, intracellular signaling, and regulation of proteins in recipient cells. We tested the hypothesis that EVs isolated from the bronchoalveolar-lavage fluid (BALF) of pediatric cystic fibrosis (CF) or pediatric asthma patients increase epithelial sodium channel (ENaC) activity in normal human small airway epithelial cells (SAECs) and the mechanism involves specific EV lipids. We characterized EVs from BALF of pediatric CF and pediatric asthma patients by nanoparticle tracking analysis, transmission electron microscopy, and Western blotting. The CF and asthma pediatric groups were similar in BALF electrolytes concentration and cell count, except for neutrophils, which were higher in the CF group. Lipidomic analyses for each group of EVs were performed using targeted mass spectrometry. Phosphatidylethanolamine, sphingomyelins, and triacylglycerol were enriched in both groups, but phosphatidylcholine and phosphatidylinositol concentrations were greater in the CF group compared to the asthma group, and the opposite trend was found for phosphatidylserine. Endogenous ENaC activity, measured by the single-channel patch-clamp technique, increased in normal human SAECs after challenging SAEC with EVs from either the CF or asthma groups compared to control EVs. In conclusion, EVs isolated from BALF of pediatric patients with CF or asthma have unique lipid profiles. Despite the differences, both types of EVs increase ENaC activity in normal human SAECs compared to control EVs isolated from the conditioned media of these cells." @default.
• W4386157352 created "2023-08-26" @default.
• W4386157352 creator A5007242435 @default.
• W4386157352 creator A5012340853 @default.
• W4386157352 creator A5015064187 @default.
• W4386157352 creator A5026771942 @default.
• W4386157352 creator A5029176765 @default.
• W4386157352 creator A5041295596 @default.
• W4386157352 creator A5085283857 @default.
• W4386157352 date "2024-01-01" @default.
• W4386157352 modified "2023-09-30" @default.
• W4386157352 title "Extracellular vesicles from BALF of pediatric cystic fibrosis and asthma patients increase epithelial sodium channel activity in small airway epithelial cells" @default.
• W4386157352 cites W1670266242 @default.
• W4386157352 cites W1946395815 @default.
• W4386157352 cites W1977692564 @default.
• W4386157352 cites W1991769617 @default.
• W4386157352 cites W1994907797 @default.
• W4386157352 cites W2031750503 @default.
• W4386157352 cites W2046758915 @default.
• W4386157352 cites W2062364311 @default.
• W4386157352 cites W2066318082 @default.
• W4386157352 cites W2108047993 @default.
• W4386157352 cites W2116180806 @default.
• W4386157352 cites W2121354606 @default.
• W4386157352 cites W2144248619 @default.
• W4386157352 cites W2144603992 @default.
• W4386157352 cites W2145346414 @default.
• W4386157352 cites W2154203503 @default.
• W4386157352 cites W2159401023 @default.
• W4386157352 cites W2170852633 @default.
• W4386157352 cites W2184964708 @default.
• W4386157352 cites W2227999806 @default.
• W4386157352 cites W2276500318 @default.
• W4386157352 cites W2288512038 @default.
• W4386157352 cites W2292155608 @default.
• W4386157352 cites W2300552860 @default.
• W4386157352 cites W2540034041 @default.
• W4386157352 cites W2547591013 @default.
• W4386157352 cites W2610315470 @default.
• W4386157352 cites W2621231288 @default.
• W4386157352 cites W2731262794 @default.
• W4386157352 cites W2800046588 @default.
• W4386157352 cites W2982704603 @default.
• W4386157352 cites W3000484238 @default.
• W4386157352 cites W3034469758 @default.
• W4386157352 cites W3041098796 @default.
• W4386157352 cites W3133990874 @default.
• W4386157352 cites W3186169729 @default.
• W4386157352 cites W4235755338 @default.
• W4386157352 doi "https://doi.org/10.1016/j.bbamem.2023.184219" @default.
• W4386157352 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37634857" @default.
• W4386157352 hasPublicationYear "2024" @default.
• W4386157352 type Work @default.
• W4386157352 citedByCount "0" @default.
• W4386157352 crossrefType "journal-article" @default.
• W4386157352 hasAuthorship W4386157352A5007242435 @default.
• W4386157352 hasAuthorship W4386157352A5012340853 @default.
• W4386157352 hasAuthorship W4386157352A5015064187 @default.
• W4386157352 hasAuthorship W4386157352A5026771942 @default.
• W4386157352 hasAuthorship W4386157352A5029176765 @default.
• W4386157352 hasAuthorship W4386157352A5041295596 @default.
• W4386157352 hasAuthorship W4386157352A5085283857 @default.
• W4386157352 hasConcept C126322002 @default.
• W4386157352 hasConcept C178790620 @default.
• W4386157352 hasConcept C185592680 @default.
• W4386157352 hasConcept C203014093 @default.
• W4386157352 hasConcept C2776042228 @default.
• W4386157352 hasConcept C2776330855 @default.
• W4386157352 hasConcept C2776938444 @default.
• W4386157352 hasConcept C2777714996 @default.
• W4386157352 hasConcept C2777961210 @default.
• W4386157352 hasConcept C2778918659 @default.
• W4386157352 hasConcept C2779637612 @default.
• W4386157352 hasConcept C2781170229 @default.
• W4386157352 hasConcept C28406088 @default.
• W4386157352 hasConcept C41625074 @default.
• W4386157352 hasConcept C537181965 @default.
• W4386157352 hasConcept C55493867 @default.
• W4386157352 hasConcept C6507245 @default.
• W4386157352 hasConcept C71924100 @default.
• W4386157352 hasConcept C79879829 @default.
• W4386157352 hasConcept C86803240 @default.
• W4386157352 hasConcept C95444343 @default.
• W4386157352 hasConceptScore W4386157352C126322002 @default.
• W4386157352 hasConceptScore W4386157352C178790620 @default.
• W4386157352 hasConceptScore W4386157352C185592680 @default.
• W4386157352 hasConceptScore W4386157352C203014093 @default.
• W4386157352 hasConceptScore W4386157352C2776042228 @default.
• W4386157352 hasConceptScore W4386157352C2776330855 @default.
• W4386157352 hasConceptScore W4386157352C2776938444 @default.
• W4386157352 hasConceptScore W4386157352C2777714996 @default.
• W4386157352 hasConceptScore W4386157352C2777961210 @default.
• W4386157352 hasConceptScore W4386157352C2778918659 @default.
• W4386157352 hasConceptScore W4386157352C2779637612 @default.
• W4386157352 hasConceptScore W4386157352C2781170229 @default.
• W4386157352 hasConceptScore W4386157352C28406088 @default.
• W4386157352 hasConceptScore W4386157352C41625074 @default.
• W4386157352 hasConceptScore W4386157352C537181965 @default.

• next