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- W4386157381 abstract "Hyperpolarized (HP) 13C Magnetic Resonance Imaging (MRI) was applied for the first time to image and quantify the uptake and metabolism of [2-13C]pyruvate in the human brain to provide new metabolic information on cerebral energy metabolism. HP [2-13C]pyruvate was injected intravenously and imaged in 5 healthy human volunteer exams with whole brain coverage in a 1-minute acquisition using a specialized spectral-spatial multi-slice echoplanar imaging (EPI) pulse sequence to acquire 13C-labeled volumetric and dynamic images of [2-13C]pyruvate and downstream metabolites [5-13C]glutamate and [2-13C]lactate. Metabolic ratios and apparent conversion rates of pyruvate-to-lactate (kPL) and pyruvate-to-glutamate (kPG) were quantified to investigate simultaneously glycolytic and oxidative metabolism in a single injection." @default.
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- W4386157381 date "2023-10-01" @default.
- W4386157381 modified "2023-10-17" @default.
- W4386157381 title "Hyperpolarized [2-13C]Pyruvate MR Molecular Imaging with Whole Brain Coverage" @default.
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- W4386157381 doi "https://doi.org/10.1016/j.neuroimage.2023.120350" @default.
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