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- W4386158647 abstract "Anterior chamber depth (ACD) is a quantitative trait associated with primary angle closure glaucoma (PACG). Although ACD is highly heritable, known genetic variations explain a small fraction of the phenotypic variability. The purpose of this study was to identify additional ACD-influencing loci using strains of mice. Cohorts of 86 N2 and 111 F2 mice were generated from crosses between recombinant inbred BXD24/TyJ and wild-derived CAST/EiJ mice. Using anterior chamber optical coherence tomography, mice were phenotyped at 10–12 weeks of age, genotyped based on 93 genome-wide SNPs, and subjected to quantitative trait locus (QTL) analysis. In an analysis of ACD among all mice, six loci passed the significance threshold of p = 0.05 and persisted after multiple regression analysis. These were on chromosomes 6, 7, 11, 12, 15 and 17 (named Acdq6 , Acdq7 , Acdq11 , Acdq12 , Acdq15 , and Acdq17 , respectively). Our findings demonstrate a quantitative multi-genic pattern of ACD inheritance in mice and identify six previously unrecognized ACD-influencing loci. We have taken a unique approach to studying the anterior chamber depth phenotype by using mice as genetic tool to examine this continuously distributed trait." @default.
- W4386158647 created "2023-08-26" @default.
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- W4386158647 date "2023-08-25" @default.
- W4386158647 modified "2023-10-05" @default.
- W4386158647 title "Anterior chamber depth in mice is controlled by several quantitative trait loci" @default.
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- W4386158647 doi "https://doi.org/10.1371/journal.pone.0286897" @default.
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