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- W4386160966 abstract "A series of pyrrole-thiazolidinone hybrids was designed, synthesized and evaluated for activities against ESKAP bacteria panel and mycobacterial pathogens. From the series, compound 9d showed prominent activity against S. aureus (MIC = 0.5 μg/mL) and compound 9k showed the most promising activity against M. tuberculosis H37Rv (MIC = 0.5 μg/mL). Potent derivatives were found to be non-toxic when tested against Vero cells. Compound 9d upon evaluation in vitro against several MRSA and VRSA strains produced activity comparable or better than standard drugs. In the anti-biofilm assay, 9d reduced S. aureus biofilm by >11% at 10x MIC. The dual inhibitory effect exhibited by pyrrole-thiazolidinone hybrids confirms their potential as new class of promising anti-infective agents." @default.
- W4386160966 created "2023-08-26" @default.
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- W4386160966 date "2023-11-01" @default.
- W4386160966 modified "2023-09-26" @default.
- W4386160966 title "Pyrrole-thiazolidinone hybrids as a new structural class of broad-spectrum anti-infectives" @default.
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- W4386160966 doi "https://doi.org/10.1016/j.ejmech.2023.115757" @default.
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