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- W4386161332 endingPage "1301" @default.
- W4386161332 startingPage "1301" @default.
- W4386161332 abstract "Neuroplasticity is a crucial property of the central nervous system to change its activity in response to intrinsic or extrinsic stimuli. This is mainly achieved through the promotion of changes in the epigenome. One of the epi-drivers priming this process is suberoylanilide hydroxamic acid (SAHA or Vorinostat), a pan-histone deacetylase inhibitor that modulates and promotes neuroplasticity in healthy and disease conditions. Knowledge of the specific molecular changes induced by this epidrug is an important area of neuro-epigenetics for the identification of new compounds to treat cognition impairment and/or epilepsy. In this review, we summarize the findings obtained in cellular and animal models of various brain disorders, highlighting the multiple mechanisms activated by SAHA, such as improvement of memory, learning and behavior, and correction of faulty neuronal functioning. Supporting this evidence, in vitro and in vivo data underline how SAHA positively regulates the expression of neuronal genes and microtubule dynamics, induces neurite outgrowth and spine density, and enhances synaptic transmission and potentiation. In particular, we outline studies regarding neurodevelopmental disorders with pharmaco-resistant seizures and/or severe cognitive impairment that to date lack effective drug treatments in which SAHA could ameliorate defective neuroplasticity." @default.
- W4386161332 created "2023-08-26" @default.
- W4386161332 creator A5037597931 @default.
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- W4386161332 creator A5069061495 @default.
- W4386161332 creator A5075368651 @default.
- W4386161332 creator A5088150642 @default.
- W4386161332 date "2023-08-24" @default.
- W4386161332 modified "2023-10-17" @default.
- W4386161332 title "Suberoylanilide Hydroxamic Acid (SAHA) Is a Driver Molecule of Neuroplasticity: Implication for Neurological Diseases" @default.
- W4386161332 cites W1506677791 @default.
- W4386161332 cites W1963792980 @default.
- W4386161332 cites W1964372470 @default.
- W4386161332 cites W1964917360 @default.
- W4386161332 cites W1971785113 @default.
- W4386161332 cites W2012203722 @default.
- W4386161332 cites W2012853055 @default.
- W4386161332 cites W2012887006 @default.
- W4386161332 cites W2043355784 @default.
- W4386161332 cites W2062483494 @default.
- W4386161332 cites W2079289532 @default.
- W4386161332 cites W2079569618 @default.
- W4386161332 cites W2083134947 @default.
- W4386161332 cites W2093208648 @default.
- W4386161332 cites W2114138025 @default.
- W4386161332 cites W2115738444 @default.
- W4386161332 cites W2117691193 @default.
- W4386161332 cites W2120815942 @default.
- W4386161332 cites W2134284348 @default.
- W4386161332 cites W2143166371 @default.
- W4386161332 cites W2151816252 @default.
- W4386161332 cites W2152868678 @default.
- W4386161332 cites W2172111362 @default.
- W4386161332 cites W2299299128 @default.
- W4386161332 cites W2510816866 @default.
- W4386161332 cites W2519531315 @default.
- W4386161332 cites W2522351325 @default.
- W4386161332 cites W2533683854 @default.
- W4386161332 cites W2612725462 @default.
- W4386161332 cites W2759433538 @default.
- W4386161332 cites W2761231592 @default.
- W4386161332 cites W2765104065 @default.
- W4386161332 cites W2770347656 @default.
- W4386161332 cites W2789385023 @default.
- W4386161332 cites W2791750284 @default.
- W4386161332 cites W2792126162 @default.
- W4386161332 cites W2808831647 @default.
- W4386161332 cites W2811414439 @default.
- W4386161332 cites W2883948616 @default.
- W4386161332 cites W2889746400 @default.
- W4386161332 cites W2900828529 @default.
- W4386161332 cites W2903507433 @default.
- W4386161332 cites W2905418919 @default.
- W4386161332 cites W2907498716 @default.
- W4386161332 cites W2920921721 @default.
- W4386161332 cites W2923166067 @default.
- W4386161332 cites W2940456023 @default.
- W4386161332 cites W2947392261 @default.
- W4386161332 cites W2955503846 @default.
- W4386161332 cites W2983368623 @default.
- W4386161332 cites W2996322519 @default.
- W4386161332 cites W3016673798 @default.
- W4386161332 cites W3029225450 @default.
- W4386161332 cites W3035511928 @default.
- W4386161332 cites W3042732942 @default.
- W4386161332 cites W3048018188 @default.
- W4386161332 cites W3106021996 @default.
- W4386161332 cites W3110098794 @default.
- W4386161332 cites W3120104279 @default.
- W4386161332 cites W3122762933 @default.
- W4386161332 cites W3128137353 @default.
- W4386161332 cites W3138965082 @default.
- W4386161332 cites W3153506497 @default.
- W4386161332 cites W3156273102 @default.
- W4386161332 cites W3157823102 @default.
- W4386161332 cites W3158189115 @default.
- W4386161332 cites W3158917465 @default.
- W4386161332 cites W3159723144 @default.
- W4386161332 cites W3162317822 @default.
- W4386161332 cites W3164759985 @default.
- W4386161332 cites W3202734787 @default.
- W4386161332 cites W3213176257 @default.
- W4386161332 cites W4200495356 @default.
- W4386161332 cites W4207083120 @default.
- W4386161332 cites W4210757201 @default.
- W4386161332 cites W4211147755 @default.
- W4386161332 cites W4225272243 @default.
- W4386161332 cites W4225562595 @default.
- W4386161332 cites W4246493659 @default.
- W4386161332 cites W4287528096 @default.
- W4386161332 cites W4320730335 @default.
- W4386161332 cites W4321002254 @default.
- W4386161332 cites W4321236378 @default.
- W4386161332 cites W4378638225 @default.
- W4386161332 doi "https://doi.org/10.3390/biom13091301" @default.
- W4386161332 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37759701" @default.
- W4386161332 hasPublicationYear "2023" @default.
- W4386161332 type Work @default.