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- W4386162912 abstract "Abstract Mono- and multiheme cytochromes c are post-translationally matured by the covalent attachment of heme. For this, Escherichia coli employs the most complex type of maturation machineries, the Ccm-system (for c ytochrome c m aturation). It consists of two membrane protein complexes, one of which shuttles heme across the membrane to a mobile chaperone that then delivers the cofactor to the second complex, an apoprotein:heme lyase, for covalent attachment. Here we report cryo-electron microscopic structures of the heme translocation complex CcmABCD from E. coli , alone and bound to the heme chaperone CcmE. CcmABCD forms a heterooctameric complex centered around the ABC transporter CcmAB that does not by itself transport heme. Our data suggest that the complex flops a heme group from the inner to the outer leaflet at its CcmBC interfaces, driven by ATP hydrolysis at CcmA. A conserved heme-handling motif (WxWD) at the periplasmic side of CcmC rotates the heme by 90° for covalent attachment to the heme chaperone CcmE that we find interacting exclusively with the CcmB subunit." @default.
- W4386162912 created "2023-08-26" @default.
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- W4386162912 date "2023-08-25" @default.
- W4386162912 modified "2023-09-23" @default.
- W4386162912 title "Architecture of the Heme-translocating CcmABCD/E complex required for Cytochrome c maturation" @default.
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- W4386162912 doi "https://doi.org/10.1038/s41467-023-40881-y" @default.
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