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- W4386163389 abstract "Interest in metal nanoparticles as nanoscale drug-carrying vehicles has been increasing. In such an aspect, lanthanide metal nanoparticles are particularly intriguing. Herein, we report praseodymium nanoparticles as a novel anticancer therapeutic transporting agent. The material was made as a composite with the supramolecular host polymer, poly-β-cyclodextrin. The praseodymium nanorods were characterized using standard analytical techniques, including X-ray diffraction (XRD), X-ray photoelectron spectroscopy (XPS), and thermogravimetric analysis (TGA). In addition, they were imaged using transmission electron microscopy. The nanostructures are a long rod-shaped material with 2.0 ± 0.1 μm in length and 230 ± 10 nm in width. The material shows a saturation magnetization value above 30 emu/g with a coercivity value of 130 Oe. The nanocarrier is freighted with the drug 5-fluorouracil, and the encapsulation efficiency is 76.09%. The drug release is continuous from the nanocarrier (polymer-containing praseodymium nanoparticles) and proceeds for above 250 h. The in vitro cytotoxicities of the blank nanocarrier and the 5-fluorouracil-loaded one are deduced by testing them on MCF-7 and Vero (non-cancerous) cell lines. The cytotoxicity on the cancerous cell lines is observed, whereas the non-cancerous cells are unaffected. The IC50 values on the cell lines are reported." @default.
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- W4386163389 date "2023-08-01" @default.
- W4386163389 modified "2023-09-25" @default.
- W4386163389 title "Praseodymium metal nanorods as a 5-fluorouracil carrier" @default.
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- W4386163389 doi "https://doi.org/10.1016/j.jre.2023.08.014" @default.
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