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- W4386165728 abstract "Word count: 248 Introduction: Bickerstaff's Encephalitis (BE) is considered a rare immune-mediated disorder, characterized by the clinical triad of ophthalmoplegia, ataxia and impaired consciousness. It falls within the spectrum of anti-GQ1b diseases. Diagnosis uses clinical and laboratory criteria, and imaging techniques allows other diseases to be ruled out. The use of 18F-fluorodeoxyglucose positron emission tomography (PET) in BE has not been extended, so a case with PET follow-up is presented. Presentation of the case: This is a 29-year-old patient, with a history of chronic headache, hypertension and grade III obesity presented 72 hours prior to admission drowsiness, ophthalmoplegia, right peripheral facial palsy, dysarthria, and gait disturbance, flaccid tetra paresis and generalized hyperreflexia. An autoimmune inflammatory disease was suspected. The determination for antiganglioside antibodies (anti GT1a IgG and anti GQ1b IgG) were positive. The diagnosis of Bickerstaff encephalitis was integrated. The main findings in the PET/CT with 18F-FDG study were cortical hypometabolism in occipital region, and cerebellum, and hypermetabolism in the striatum bilaterally, with normalization of the brain metabolism after treatment on the second PET-FDG scan performed after 4 months of onset of the clinical picture. Conclusion: We demonstrate a case of BE by molecular imaging with PET-FDG before and after treatment with normalization of brain metabolism with cognitive improvement. Molecular Imaging has a potential in the diagnostic, and monitoring evaluations of BE. PET (Positron Emission Tomography) could be an earlier marker for neurological conditions as BE and an excellent tool to aid diagnosis, to provide timely treatment and follow-up BE patients." @default.
- W4386165728 created "2023-08-26" @default.
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- W4386165728 date "2023-08-24" @default.
- W4386165728 modified "2023-10-17" @default.
- W4386165728 title "Case report: 18F-FDG PET-CT findings in Bickerstaff encephalitis before and after treatment" @default.
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- W4386165728 doi "https://doi.org/10.3389/fnume.2023.1235173" @default.
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