Matches in SemOpenAlex for { <https://semopenalex.org/work/W4386168471> ?p ?o ?g. }
- W4386168471 abstract "Human height is strongly influenced by genetics but the contribution of modifiable epigenetic factors is under-explored, particularly in low and middle-income countries (LMIC). We investigate links between blood DNA methylation and child height in four LMIC cohorts (n = 1927) and identify a robust association at three CpGs in the suppressor of cytokine signaling 3 (SOCS3) gene which replicates in a high-income country cohort (n = 879). SOCS3 methylation (SOCS3m)-height associations are independent of genetic effects. Mendelian randomization analysis confirms a causal effect of SOCS3m on height. In longitudinal analysis, SOCS3m explains a maximum 9.5% of height variance in mid-childhood while the variance explained by height polygenic risk score increases from birth to 21 years. Children's SOCS3m is associated with prenatal maternal folate and socio-economic status. In-vitro characterization confirms a regulatory effect of SOCS3m on gene expression. Our findings suggest epigenetic modifications may play an important role in driving child height in LMIC." @default.
- W4386168471 created "2023-08-26" @default.
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- W4386168471 date "2023-08-25" @default.
- W4386168471 modified "2023-10-15" @default.
- W4386168471 title "DNA methylation at the suppressor of cytokine signaling 3 (SOCS3) gene influences height in childhood" @default.
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