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- W4386170148 endingPage "121334" @default.
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- W4386170148 abstract "Polyguluronic acid (PG), a polysaccharide from alginate, possesses excellent bioactivities. We prepared high-purity PG with 10.41 kDa molecular weight (Mw) and a 59 average degree of polymerization (DP) by acid hydrolysis, three pH grades, Q-Sepharose column elution, and Sephadex G-25 column desalination. Then, we evaluated the PG protective effects on doxorubicin-induced cardiotoxicity (DIC) in vitro and in vivo. The nontoxic PG enhanced cellular viability, reduced cell pyroptosis morphology, diminished the LDH and IL-1β release, and downregulated expressions of ASC oligomerization, NLRP3, cl-CASP1, and GSDMD, by which PG protected the cardiomyocytes from NLRP3 inflammasome-mediated pyroptosis in doxorubicin-stimulated HL-1 cells and C57BL/6J mice. The probable underlying mechanism may be that PG downregulated doxorubicin -induced Peli1, the deficiency of which could inhibit doxorubicin-induced NLRP3 inflammasome-mediated pyroptosis. These results suggested that polysaccharide PG from alginate could prevent DIC and may be a potential therapeutic agent or bioactive material for preventing DIC." @default.
- W4386170148 created "2023-08-26" @default.
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- W4386170148 date "2023-12-01" @default.
- W4386170148 modified "2023-10-14" @default.
- W4386170148 title "Polyguluronic acid alleviates doxorubicin-induced cardiotoxicity by suppressing Peli1-NLRP3 inflammasome-mediated pyroptosis" @default.
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- W4386170148 doi "https://doi.org/10.1016/j.carbpol.2023.121334" @default.
- W4386170148 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37739547" @default.
- W4386170148 hasPublicationYear "2023" @default.
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