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• W4386170491 startingPage "155048" @default.
• W4386170491 abstract ": Benign prostatic hyperplasia (BPH) is a common disease in older men worldwide. However, there is currently no effective treatment for BPH. Bushen Tongluo Formula (Kidney-supplementing and collaterals-unblocking formula [KCF]) is a traditional Chinese medicine formula commonly used to ameliorate the symptoms of BPH, although the specific molecular mechanisms remain unclear. : We aimed to discover the effects and potential mechanisms of KCF against BPH. : Sixty male SD rats were randomly assigned to one of six group (n = 10): control, low-dosage KCF, medium-dosage KCF, high-dosage KCF, BPH model, and finasteride. A rat model of BPH was established by surgical castration followed by subcutaneous injection of testosterone propionate (TP) for 4 weeks. After treatment, the prostate index, histopathological staining, serum levels of estradiol (E2) and dihydrotestosterone (DHT), protein/mRNA levels of E-cadherin, TGF-β1, caspase-3, Ki67, and vimentin, abundances of serum metabolites, and the proliferation, cell cycle, and apoptosis of BPH-1 cells were documented. : KCF treatment for 4 weeks reduced the prostate volume and prostate index, alleviated histopathological changes to the prostate of rats with TP-induced BPH, decreased serum levels of E2 and DHT, reduced protein/mRNA levels of TGF-β1 and vimentin, and increased E-cadherin levels. Moreover, KCF-spiked serum inhibited proliferation of BPH-1 cells, blocked the cell cycle, and promoted apoptosis. KCF was also found to regulate the contents of three metabolites (D-maltose, citric acid, and fumaric acid). : The present study was the first to report that KCF exhibited therapeutic effects against BPH by regulating energy metabolism and inhibiting epithelial–mesenchymal transition in prostate tissues. Hence, KCF presents a viable treatment option for BPH." @default.
• W4386170491 created "2023-08-26" @default.
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• W4386170491 date "2023-11-01" @default.
• W4386170491 modified "2023-09-26" @default.
• W4386170491 title "Bushen Tongluo formula ameliorated testosterone propionate-induced benign prostatic hyperplasia in rats" @default.
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• W4386170491 doi "https://doi.org/10.1016/j.phymed.2023.155048" @default.
• W4386170491 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37651753" @default.
• W4386170491 hasPublicationYear "2023" @default.
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