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- W4386171585 endingPage "102041" @default.
- W4386171585 startingPage "102041" @default.
- W4386171585 abstract "Aging is a complex natural process that leads to a decline in physiological functions, which is visible in signs such as hair graying, thinning, and loss. Although hair graying is characterized by a loss of pigment in the hair shaft, the underlying mechanism of age-associated hair graying is not fully understood. Hair graying and loss can have a significant impact on an individual's self-esteem and self-confidence, potentially leading to mental health problems such as depression and anxiety. Omics technologies, which have applications beyond clinical medicine, have led to the discovery of candidate hair biomarkers and may provide insight into the complex biology of hair aging and identify targets for effective therapies. This review provides an up-to-date overview of recent omics discoveries, including age-associated alterations of proteins and metabolites in the hair shaft and follicle, and highlights the significance of hair aging and graying biomarker discoveries. The decline in hair follicle stem cell activity with aging decreased the regeneration capacity of hair follicles. Cellular senescence, oxidative damage and altered extracellular matrix of hair follicle constituents characterized hair follicle and hair shaft aging and graying. The review attempts to correlate the impact of endogenous and exogenous factors on hair aging. We close by discussing the main challenges and limitations of the field, defining major open questions and offering an outook for future research." @default.
- W4386171585 created "2023-08-26" @default.
- W4386171585 creator A5030098277 @default.
- W4386171585 creator A5058972430 @default.
- W4386171585 date "2023-11-01" @default.
- W4386171585 modified "2023-10-14" @default.
- W4386171585 title "Recent Omics Advances in Hair Aging Biology and Hair Biomarkers Analysis" @default.
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