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- W4386189804 abstract "Existing antibacterial agents can be categorized into two generations, but bacterial insensitivity towards both of these classes poses a serious public health challenge worldwide. Thus, novel approaches and/or novel antibacterials are urgently needed to maintain a concentration of antibacterials that is lethal to bacteria that are resistant to existing antibiotic treatments. Metabolite(s)-based adjuvants that promote antibiotic uptake and enhance antibiotic efficacy are an effective strategy that is unlikely to develop resistance. Thus, we propose a metabolite(s)-based approach, in which metabolites and antibacterials are combined, as a promising strategy for the development of next-generation agents to combat a variety of antibiotic-resistant pathogens." @default.
- W4386189804 created "2023-08-27" @default.
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- W4386189804 date "2023-10-01" @default.
- W4386189804 modified "2023-10-16" @default.
- W4386189804 title "Call for next-generation drugs that remove the uptake barrier to combat antibiotic resistance" @default.
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- W4386189804 doi "https://doi.org/10.1016/j.drudis.2023.103753" @default.
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