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- W4386195199 abstract "One of the fundamental goals of most linkage studies is to localize a gene believed to be responsible for a trait locus by the investigation of its co-segregation with a genetic marker. Statistical techniques for linkage investigations have been introduced in the early 1930's. These were followed by the introduction of the log-odds approach (Morton 1955; Smith 1963) which provided standard methods to report and analyze linkage data collected from independent sib-ships. Because of the heterogeneity in the manner diseases affect families, use of the standard log-odds approach will result in a considerable reduction i the statistical power to detect linkage between disease trait and marker loci. This paper investigates the asymptotic properties of statistical tests that would be used to detect linkage under heterogeneity." @default.
- W4386195199 created "2023-08-27" @default.
- W4386195199 date "2003-06-01" @default.
- W4386195199 modified "2023-09-25" @default.
- W4386195199 title "Likelihood Ratio and Score Tests for Heterogeneity in Genetic Linkage" @default.
- W4386195199 doi "https://doi.org/10.21608/esju.2003.313775" @default.
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