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• W4386201158 abstract "Abstract Aims To summarize the totality of evidence validating the Predicting Bleeding Complications in Patients Undergoing Stent Implantation and Subsequent Dual Antiplatelet Therapy (PRECISE-DAPT) score, ascertaining its aggregate discrimination and validation power in multiple population subsets. Methods and results We searched electronic databases from 2017 (PRECISE-DAPT proposal) up to March 2023 for studies that reported the occurrence of out-of-hospital bleedings according to the PRECISE-DAPT score in patients receiving DAPT following percutaneous coronary intervention (PCI). Pooled odds ratios (OR) with 95% confidence interval (CI) were used as summary statistics and were calculated using a random-effects model. Primary and secondary endpoints were the occurrence of any and major bleeding, respectively. A total of 21 studies and 67 283 patients were included; 24.7% of patients (N = 16 603) were at high bleeding risk (PRECISE-DAPT score ≥25), and when compared to those at low bleeding risk, they experienced a significantly higher rate of any out-of-hospital bleeding (OR: 2.71; 95% CI: 2.24–3.29; P-value &lt;0.001) and major bleedings (OR: 3.51; 95% CI: 2.71–4.55; P-value &lt;0.001). Pooling data on c-stat whenever available, the PRECISE-DAPT score showed a moderate discriminative power in predicting major bleeding events at 1 year (pooled c-stat: 0.71; 95% CI: 0.64–0.77). Conclusion This systematic review and meta-analysis confirms the external validity of the PRECISE-DAPT score in predicting out-of-hospital bleeding outcomes in patients on DAPT following PCI. The moderate discriminative ability highlights the need for future improved risk prediction tools in the field." @default.
• W4386201158 created "2023-08-28" @default.
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• W4386201158 date "2023-08-26" @default.
• W4386201158 modified "2023-10-14" @default.
• W4386201158 title "External validity of the PRECISE-DAPT score in patients undergoing PCI: a systematic review and meta-analysis" @default.
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• W4386201158 doi "https://doi.org/10.1093/ehjcvp/pvad063" @default.
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