Matches in SemOpenAlex for { <https://semopenalex.org/work/W4386203834> ?p ?o ?g. }
Showing items 1 to 67 of
67
with 100 items per page.
- W4386203834 abstract "Syzygium aromaticum seed from the family of Myrtaceae is a highly priced natural spice used in preparation of food which have been acclaimed and reported by previous researchers to have anticancer activities potentials. Due to the rising burden of cancer worldwide its severity and fatality coupled with side effects of synthetic drugs calls for an alternative treatment solution. Hence the current research studied the phytocompounds from the seed by extracting and screening the compounds using solvent maceration method and gas chromatography coupled to mass selective detector respectively to extract, identify and quantify the component phytochemicals present in the seed. Site directed multi-ligand docking of the identified compounds was performance on progesterone receptor protein responsible for breast cancer development using the compounds from GCMS results and compared with four standard breast cancer drugs by molecular docking method. The result showed that the alpha cubebene (-7 kcal/mol), Velerena -4, 7- (II) diene (-7.1 kcal/mol), caryophyllene (-7.4 kcal/mol), caryophyllene oxide (-7.4 kcal/mol), dibutyl phthalate have binding affinity close to the standard breast cancer drugs Abemaciclib (-8.3), Anastrozole (-7.2 kcal/mol) and Paclitaxel (-8.8 kcal/mol) and they have better binding affinity than the drug Cyclophasphamide (-5.6 kcal/mol). The result also revealed that some compounds from the GC-MS were found to have a binding affinity closer tothat of thecocrystallized ligand (-10.7 kcal/mol). Other compounds from clove seed showed favourable docking scores in comparison with the drugs as many of the compounds have docking scores of more than (-6 kcal/mol) suggesting that the compounds have anti breast cancer activities since their amino acids showed hydrogen bonding corresponding to that on the binding site" @default.
- W4386203834 created "2023-08-28" @default.
- W4386203834 creator A5000321666 @default.
- W4386203834 creator A5003741628 @default.
- W4386203834 creator A5035187495 @default.
- W4386203834 creator A5036998735 @default.
- W4386203834 creator A5044880348 @default.
- W4386203834 date "2023-08-27" @default.
- W4386203834 modified "2023-10-16" @default.
- W4386203834 title "INSILICO DETERMINATION OF ANTI CANCER ACTIVITY OF PHYTOCHEMICAL FROM CLOVE (Syzygium aromaticum L) SEED" @default.
- W4386203834 doi "https://doi.org/10.46602/jcsn.v48i4.911" @default.
- W4386203834 hasPublicationYear "2023" @default.
- W4386203834 type Work @default.
- W4386203834 citedByCount "0" @default.
- W4386203834 crossrefType "journal-article" @default.
- W4386203834 hasAuthorship W4386203834A5000321666 @default.
- W4386203834 hasAuthorship W4386203834A5003741628 @default.
- W4386203834 hasAuthorship W4386203834A5035187495 @default.
- W4386203834 hasAuthorship W4386203834A5036998735 @default.
- W4386203834 hasAuthorship W4386203834A5044880348 @default.
- W4386203834 hasBestOaLocation W43862038341 @default.
- W4386203834 hasConcept C159110408 @default.
- W4386203834 hasConcept C178790620 @default.
- W4386203834 hasConcept C185592680 @default.
- W4386203834 hasConcept C195475562 @default.
- W4386203834 hasConcept C2777423695 @default.
- W4386203834 hasConcept C2779643248 @default.
- W4386203834 hasConcept C2781325065 @default.
- W4386203834 hasConcept C41685203 @default.
- W4386203834 hasConcept C55493867 @default.
- W4386203834 hasConcept C556039675 @default.
- W4386203834 hasConcept C59822182 @default.
- W4386203834 hasConcept C71240020 @default.
- W4386203834 hasConcept C71924100 @default.
- W4386203834 hasConcept C86803240 @default.
- W4386203834 hasConceptScore W4386203834C159110408 @default.
- W4386203834 hasConceptScore W4386203834C178790620 @default.
- W4386203834 hasConceptScore W4386203834C185592680 @default.
- W4386203834 hasConceptScore W4386203834C195475562 @default.
- W4386203834 hasConceptScore W4386203834C2777423695 @default.
- W4386203834 hasConceptScore W4386203834C2779643248 @default.
- W4386203834 hasConceptScore W4386203834C2781325065 @default.
- W4386203834 hasConceptScore W4386203834C41685203 @default.
- W4386203834 hasConceptScore W4386203834C55493867 @default.
- W4386203834 hasConceptScore W4386203834C556039675 @default.
- W4386203834 hasConceptScore W4386203834C59822182 @default.
- W4386203834 hasConceptScore W4386203834C71240020 @default.
- W4386203834 hasConceptScore W4386203834C71924100 @default.
- W4386203834 hasConceptScore W4386203834C86803240 @default.
- W4386203834 hasIssue "4" @default.
- W4386203834 hasLocation W43862038341 @default.
- W4386203834 hasOpenAccess W4386203834 @default.
- W4386203834 hasPrimaryLocation W43862038341 @default.
- W4386203834 hasRelatedWork W2208567795 @default.
- W4386203834 hasRelatedWork W2604088915 @default.
- W4386203834 hasRelatedWork W2725927837 @default.
- W4386203834 hasRelatedWork W2742564950 @default.
- W4386203834 hasRelatedWork W2770998094 @default.
- W4386203834 hasRelatedWork W2789762863 @default.
- W4386203834 hasRelatedWork W3000961064 @default.
- W4386203834 hasRelatedWork W3134710240 @default.
- W4386203834 hasRelatedWork W4225755444 @default.
- W4386203834 hasRelatedWork W2184385807 @default.
- W4386203834 hasVolume "48" @default.
- W4386203834 isParatext "false" @default.
- W4386203834 isRetracted "false" @default.
- W4386203834 workType "article" @default.