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- W4386204292 abstract "Son yıllarda keşfedilen CRISPR-Cas sistemi, CRISPR dizileri (düzenli aralıklarla bölünmüş palindromik tekrar kümeleri) ve Cas (CRISPR ilişkili proteinler) genlerinden oluşmaktadır. 1987 yılında bu tekrar kümeleri ilk olarak Escherichia coli’de keşfedilmiş ancak fonksiyonları tanımlanamamıştır. Günümüzde Salmonella da dahil olmak üzere bakteri genomlarının yaklaşık % 45'inde bulunan CRISPR-Cas sisteminin bakterilerin nükleik asit tabanlı adaptif bağışıklık sisteminin temel bileşenleri olduğu bilinmektedir. CRISPR-Cas bölgelerinin analizine dayalı çalışmaların son yıllarda oldukça artması, CRISPR tabanlı teknolojilerin ve uygulamaların çoğalması bu alanda yapılan çalışmaların etkinliğini de giderek artırmaktadır. Bu derlemede CRISPR-Cas sistemi ve Salmonella’da mevcut olan CRISPR bölge özellikleri ile kullanım alanları hakkında bilgi verilecektir" @default.
- W4386204292 created "2023-08-28" @default.
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- W4386204292 date "2023-09-01" @default.
- W4386204292 modified "2023-10-03" @default.
- W4386204292 title "SALMONELLA CRISPR-Cas SİSTEMİ’NİN TEMEL ÖZELLİKLERİ" @default.
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- W4386204292 doi "https://doi.org/10.38137/vftd.1208878" @default.
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