FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4386204382> ?p ?o ?g. }

• W4386204382 endingPage "100126" @default.
• W4386204382 startingPage "100126" @default.
• W4386204382 abstract "Psychiatric disorders characterized by uncontrolled reward seeking, such as substance use disorders (SUDs), alcohol use disorder (AUD) and some eating disorders, impose a significant burden on individuals and society. Despite their high prevalence and substantial morbidity and mortality rates, treatment options for these disorders remain limited. Over the past two decades, there has been a gradual accumulation of evidence pointing to the sigma-1 receptor (S1R) system as a promising target for therapeutic interventions designed to treat these disorders. S1R is a chaperone protein that resides in the endoplasmic reticulum, but under certain conditions translocates to the plasma membrane. In the brain, S1Rs are expressed in several regions important for reward, and following translocation, they physically associate with several reward-related GPCRs, including dopamine receptors 1 and 2 (D1R and D2R). Psychostimulants, alcohol, as well as palatable foods, all alter expression of S1R in regions important for motivated behavior, and S1R antagonists generally decrease behavioral responses to these rewards. Recent advances in structural modeling have permitted the development of highly-selective S1R antagonists with favorable pharmacokinetic profiles, thus providing a therapeutic avenue for S1R-based medications. Here, we provide an up-to-date overview of work linking S1R with motivated behavior for drugs of abuse and food, as well as evidence supporting the clinical utility of S1R antagonists to reduce their excessive consumption. We also highlight potential challenges associated with targeting the S1R system, including the need for a more comprehensive understanding of the underlying neurobiology and careful consideration of the pharmacological properties of S1R-based drugs." @default.
• W4386204382 created "2023-08-28" @default.
• W4386204382 creator A5034771202 @default.
• W4386204382 creator A5040244335 @default.
• W4386204382 creator A5067391661 @default.
• W4386204382 creator A5069238430 @default.
• W4386204382 creator A5092703541 @default.
• W4386204382 date "2023-12-01" @default.
• W4386204382 modified "2023-10-05" @default.
• W4386204382 title "Recent advances in drug discovery efforts targeting the sigma 1 receptor system: Implications for novel medications designed to reduce excessive drug and food seeking" @default.
• W4386204382 cites W1623883571 @default.
• W4386204382 cites W1695278265 @default.
• W4386204382 cites W1856376394 @default.
• W4386204382 cites W1900414416 @default.
• W4386204382 cites W1907753293 @default.
• W4386204382 cites W1971812417 @default.
• W4386204382 cites W1971870927 @default.
• W4386204382 cites W1973130035 @default.
• W4386204382 cites W1973566728 @default.
• W4386204382 cites W1975194296 @default.
• W4386204382 cites W1977829039 @default.
• W4386204382 cites W1979826545 @default.
• W4386204382 cites W1980648631 @default.
• W4386204382 cites W1986134784 @default.
• W4386204382 cites W1986595272 @default.
• W4386204382 cites W1988973849 @default.
• W4386204382 cites W1988997816 @default.
• W4386204382 cites W1990111277 @default.
• W4386204382 cites W1992633035 @default.
• W4386204382 cites W1994224293 @default.
• W4386204382 cites W1995552213 @default.
• W4386204382 cites W2001142399 @default.
• W4386204382 cites W2002439304 @default.
• W4386204382 cites W2003532781 @default.
• W4386204382 cites W2004873892 @default.
• W4386204382 cites W2011766778 @default.
• W4386204382 cites W2023202438 @default.
• W4386204382 cites W2027105757 @default.
• W4386204382 cites W2031936045 @default.
• W4386204382 cites W2034611641 @default.
• W4386204382 cites W2046533457 @default.
• W4386204382 cites W2047599785 @default.
• W4386204382 cites W2050563394 @default.
• W4386204382 cites W2055679400 @default.
• W4386204382 cites W2056028912 @default.
• W4386204382 cites W2060070131 @default.
• W4386204382 cites W2060650451 @default.
• W4386204382 cites W2062709038 @default.
• W4386204382 cites W2065494118 @default.
• W4386204382 cites W2066524249 @default.
• W4386204382 cites W2067901635 @default.
• W4386204382 cites W2073373337 @default.
• W4386204382 cites W2089108699 @default.
• W4386204382 cites W2102067349 @default.
• W4386204382 cites W2107844030 @default.
• W4386204382 cites W2112286580 @default.
• W4386204382 cites W2115771625 @default.
• W4386204382 cites W2125368083 @default.
• W4386204382 cites W2129373115 @default.
• W4386204382 cites W2131394959 @default.
• W4386204382 cites W2133361268 @default.
• W4386204382 cites W2143528822 @default.
• W4386204382 cites W2144768754 @default.
• W4386204382 cites W2146915995 @default.
• W4386204382 cites W2148418924 @default.
• W4386204382 cites W2156780489 @default.
• W4386204382 cites W2312675938 @default.
• W4386204382 cites W2314811232 @default.
• W4386204382 cites W2324379716 @default.
• W4386204382 cites W2341902059 @default.
• W4386204382 cites W2419900567 @default.
• W4386204382 cites W2564690222 @default.
• W4386204382 cites W2566998941 @default.
• W4386204382 cites W2595791653 @default.
• W4386204382 cites W2614102372 @default.
• W4386204382 cites W2618221287 @default.
• W4386204382 cites W2620588943 @default.
• W4386204382 cites W264617763 @default.
• W4386204382 cites W2653360235 @default.
• W4386204382 cites W2764219201 @default.
• W4386204382 cites W2765629239 @default.
• W4386204382 cites W2768166779 @default.
• W4386204382 cites W2773453461 @default.
• W4386204382 cites W278711765 @default.
• W4386204382 cites W2791402446 @default.
• W4386204382 cites W2801697874 @default.
• W4386204382 cites W2807734670 @default.
• W4386204382 cites W2909934293 @default.
• W4386204382 cites W2910949748 @default.
• W4386204382 cites W2946355129 @default.
• W4386204382 cites W2947462912 @default.
• W4386204382 cites W2957842142 @default.
• W4386204382 cites W2958494286 @default.
• W4386204382 cites W2973712670 @default.
• W4386204382 cites W2991006743 @default.
• W4386204382 cites W2998767488 @default.
• W4386204382 cites W3001431236 @default.
• W4386204382 cites W3047831484 @default.

• next