FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4386211674> ?p ?o ?g. }

• W4386211674 abstract "Abstract Background Repeated sessions of training and non-invasive brain stimulation have the potential to enhance cognition in patients with cognitive impairment. We hypothesized that combining cognitive training with anodal transcranial direct current stimulation (tDCS) will lead to performance improvement in the trained task and yield transfer to non-trained tasks. Methods In our randomized, sham-controlled, double-blind study, 46 patients with cognitive impairment (60–80 years) were randomly assigned to one of two interventional groups. We administered a 9-session cognitive training (consisting of a letter updating and a Markov decision-making task) over 3 weeks with concurrent 1-mA anodal tDCS over left dorsolateral prefrontal cortex (20 min in tDCS, 30 sec in sham group). Primary outcome was trained task performance (letter updating task) immediately after training. Secondary outcomes included performance in tasks testing working memory (N-back task), decision-making (Wiener Matrices test) and verbal memory (verbal learning and memory test), and resting-state functional connectivity (FC). Tasks were administered at baseline, at post-assessment, and at 1- and 7-month follow-ups (FU). MRI was conducted at baseline and 7-month FU. Thirty-nine participants (85%) successfully completed the intervention. Data analyses are reported on the intention-to-treat (ITT) and the per-protocol (PP) sample. Results For the primary outcome, no difference was observed in ITT or PP sample. However, the tDCS outperformed the sham group in the N-back working memory task. Frontoparietal network FC was increased from baseline to 7-month FU in the tDCS compared to the sham group. Exploratory analyses showed a correlation between individual memory improvements and higher electric field magnitudes induced by tDCS. Adverse events did not differ between groups, questionnaires indicated successful blinding. Conclusions In sum, cognitive training with concurrent brain stimulation induced transferred working memory benefits in patients with cognitive impairment who underwent the full 3-week intervention. MRI data pointed toward a potential intervention-induced modulation of neural network dynamics. A link between individual performance gains and electric fields suggested dosage-dependent effects of brain stimulation. Together, our findings show that the combined intervention might be a potential treatment option in patients with cognitive impairment. Future research needs to explore whether individualized protocols for both training and stimulation parameters might further enhance treatment gains. Trial registration The study is registered on ClinicalTrials.gov (NCT04265378). Registered on 7 February 2020. Retrospectively registered." @default.
• W4386211674 created "2023-08-29" @default.
• W4386211674 creator A5006714147 @default.
• W4386211674 creator A5028455492 @default.
• W4386211674 creator A5031375223 @default.
• W4386211674 creator A5041380550 @default.
• W4386211674 creator A5049657045 @default.
• W4386211674 creator A5059687755 @default.
• W4386211674 creator A5069959120 @default.
• W4386211674 creator A5083929597 @default.
• W4386211674 creator A5088743625 @default.
• W4386211674 date "2023-08-28" @default.
• W4386211674 modified "2023-10-17" @default.
• W4386211674 title "Training and brain stimulation in patients with cognitive impairment: a randomized controlled trial" @default.
• W4386211674 cites W1695351344 @default.
• W4386211674 cites W1966033721 @default.
• W4386211674 cites W1971734091 @default.
• W4386211674 cites W1972773714 @default.
• W4386211674 cites W1973776237 @default.
• W4386211674 cites W1983183519 @default.
• W4386211674 cites W1987599891 @default.
• W4386211674 cites W2000697043 @default.
• W4386211674 cites W2004293194 @default.
• W4386211674 cites W2005238835 @default.
• W4386211674 cites W2014405462 @default.
• W4386211674 cites W2048505725 @default.
• W4386211674 cites W2051222601 @default.
• W4386211674 cites W2054454468 @default.
• W4386211674 cites W2055362996 @default.
• W4386211674 cites W2063237661 @default.
• W4386211674 cites W2067693209 @default.
• W4386211674 cites W2067799130 @default.
• W4386211674 cites W2068375947 @default.
• W4386211674 cites W2073568238 @default.
• W4386211674 cites W2081320562 @default.
• W4386211674 cites W2082526227 @default.
• W4386211674 cites W2101135654 @default.
• W4386211674 cites W2109645124 @default.
• W4386211674 cites W2117970542 @default.
• W4386211674 cites W2130010412 @default.
• W4386211674 cites W2139886607 @default.
• W4386211674 cites W2150696106 @default.
• W4386211674 cites W2155298532 @default.
• W4386211674 cites W2320359820 @default.
• W4386211674 cites W2330493848 @default.
• W4386211674 cites W2336883359 @default.
• W4386211674 cites W2592199539 @default.
• W4386211674 cites W2593974732 @default.
• W4386211674 cites W2604508934 @default.
• W4386211674 cites W2616004589 @default.
• W4386211674 cites W2650613126 @default.
• W4386211674 cites W2686038515 @default.
• W4386211674 cites W2757683506 @default.
• W4386211674 cites W2759480366 @default.
• W4386211674 cites W2784013409 @default.
• W4386211674 cites W2891324318 @default.
• W4386211674 cites W2921724998 @default.
• W4386211674 cites W2968808702 @default.
• W4386211674 cites W2973351917 @default.
• W4386211674 cites W2977883299 @default.
• W4386211674 cites W2979888413 @default.
• W4386211674 cites W2996309028 @default.
• W4386211674 cites W3004493719 @default.
• W4386211674 cites W3034190502 @default.
• W4386211674 cites W3091045979 @default.
• W4386211674 cites W3092211278 @default.
• W4386211674 cites W3095054664 @default.
• W4386211674 cites W3122425186 @default.
• W4386211674 cites W3158867864 @default.
• W4386211674 cites W3175430908 @default.
• W4386211674 cites W3214554053 @default.
• W4386211674 cites W4230920194 @default.
• W4386211674 cites W4241074797 @default.
• W4386211674 cites W4285707174 @default.
• W4386211674 cites W4379197439 @default.
• W4386211674 doi "https://doi.org/10.21203/rs.3.rs-3288743/v1" @default.
• W4386211674 hasPublicationYear "2023" @default.
• W4386211674 type Work @default.
• W4386211674 citedByCount "0" @default.
• W4386211674 crossrefType "posted-content" @default.
• W4386211674 hasAuthorship W4386211674A5006714147 @default.
• W4386211674 hasAuthorship W4386211674A5028455492 @default.
• W4386211674 hasAuthorship W4386211674A5031375223 @default.
• W4386211674 hasAuthorship W4386211674A5041380550 @default.
• W4386211674 hasAuthorship W4386211674A5049657045 @default.
• W4386211674 hasAuthorship W4386211674A5059687755 @default.
• W4386211674 hasAuthorship W4386211674A5069959120 @default.
• W4386211674 hasAuthorship W4386211674A5083929597 @default.
• W4386211674 hasAuthorship W4386211674A5088743625 @default.
• W4386211674 hasBestOaLocation W43862116741 @default.
• W4386211674 hasConcept C126322002 @default.
• W4386211674 hasConcept C15744967 @default.
• W4386211674 hasConcept C162324750 @default.
• W4386211674 hasConcept C168563851 @default.
• W4386211674 hasConcept C169760540 @default.
• W4386211674 hasConcept C169900460 @default.
• W4386211674 hasConcept C185711340 @default.
• W4386211674 hasConcept C187736073 @default.
• W4386211674 hasConcept C21963081 @default.
• W4386211674 hasConcept C24998067 @default.

• next