Matches in SemOpenAlex for { <https://semopenalex.org/work/W4386220290> ?p ?o ?g. }
- W4386220290 abstract "A memory engram is thought to be the physical substrate of the memory trace within the brain, which is generally depicted as a neuronal ensemble activated by learning to fire together during encoding and retrieval. It has been postulated that engram cell ensembles are functionally interconnected across multiple brain regions to store a single memory as an “engram complex”, but visualizing this engram complex across the whole brain has for long been hindered by technical limitations. With the recent development of tissue clearing techniques, advanced light-sheet microscopy, and automated 3D image analysis, it has now become possible to generate a brain-wide map of engram cells and thereby to visualize the “engram complex”. In this review, we first provide a comprehensive summary of brain-wide engram mapping studies to date. We then compile a guide on implementing the optimal tissue clearing technique for engram tagging approaches, paying particular attention to visualize engram reactivation as a critical mnemonic property, for which whole-brain multiplexed immunostaining becomes a challenging prerequisite. Finally, we highlight the potential of tissue clearing to simultaneously shed light on both the circuit connectivity and molecular underpinnings of engram cells in a single snapshot. In doing so, novel brain regions and circuits can be identified for subsequent functional manipulation, thus providing an opportunity to robustly examine the “engram complex” underlying memory storage." @default.
- W4386220290 created "2023-08-29" @default.
- W4386220290 creator A5044016332 @default.
- W4386220290 creator A5092707607 @default.
- W4386220290 date "2023-08-28" @default.
- W4386220290 modified "2023-09-30" @default.
- W4386220290 title "Tissue clearing applications in memory engram research" @default.
- W4386220290 cites W1547865271 @default.
- W4386220290 cites W1591199750 @default.
- W4386220290 cites W1920095995 @default.
- W4386220290 cites W1937980604 @default.
- W4386220290 cites W1968714114 @default.
- W4386220290 cites W1972768039 @default.
- W4386220290 cites W1985534367 @default.
- W4386220290 cites W1991749957 @default.
- W4386220290 cites W1995227930 @default.
- W4386220290 cites W1999653836 @default.
- W4386220290 cites W2001477070 @default.
- W4386220290 cites W2010956007 @default.
- W4386220290 cites W2024758252 @default.
- W4386220290 cites W2029083932 @default.
- W4386220290 cites W2042007511 @default.
- W4386220290 cites W2053228750 @default.
- W4386220290 cites W2053308907 @default.
- W4386220290 cites W2062022610 @default.
- W4386220290 cites W2062843325 @default.
- W4386220290 cites W2065311834 @default.
- W4386220290 cites W2068391384 @default.
- W4386220290 cites W2076507262 @default.
- W4386220290 cites W2081943776 @default.
- W4386220290 cites W2082235945 @default.
- W4386220290 cites W2083750191 @default.
- W4386220290 cites W2084252221 @default.
- W4386220290 cites W2085974955 @default.
- W4386220290 cites W2089564920 @default.
- W4386220290 cites W2089817334 @default.
- W4386220290 cites W2094944422 @default.
- W4386220290 cites W2104742248 @default.
- W4386220290 cites W2110659025 @default.
- W4386220290 cites W2113132656 @default.
- W4386220290 cites W2115736681 @default.
- W4386220290 cites W2120197531 @default.
- W4386220290 cites W2133083344 @default.
- W4386220290 cites W2143082392 @default.
- W4386220290 cites W2143414696 @default.
- W4386220290 cites W2143524000 @default.
- W4386220290 cites W2155505956 @default.
- W4386220290 cites W2157468016 @default.
- W4386220290 cites W2158586519 @default.
- W4386220290 cites W2160934587 @default.
- W4386220290 cites W2161853532 @default.
- W4386220290 cites W2195858147 @default.
- W4386220290 cites W2203529929 @default.
- W4386220290 cites W2284497151 @default.
- W4386220290 cites W2299967951 @default.
- W4386220290 cites W2397854701 @default.
- W4386220290 cites W2401518220 @default.
- W4386220290 cites W2406725268 @default.
- W4386220290 cites W2408110716 @default.
- W4386220290 cites W2465504877 @default.
- W4386220290 cites W2514163892 @default.
- W4386220290 cites W2583072564 @default.
- W4386220290 cites W2601947439 @default.
- W4386220290 cites W2604988916 @default.
- W4386220290 cites W2605615531 @default.
- W4386220290 cites W2801760391 @default.
- W4386220290 cites W2802421842 @default.
- W4386220290 cites W2802879036 @default.
- W4386220290 cites W2803335887 @default.
- W4386220290 cites W2808647362 @default.
- W4386220290 cites W2887950003 @default.
- W4386220290 cites W2888174646 @default.
- W4386220290 cites W2888526386 @default.
- W4386220290 cites W2894908641 @default.
- W4386220290 cites W2895701510 @default.
- W4386220290 cites W2898137459 @default.
- W4386220290 cites W2898444937 @default.
- W4386220290 cites W2904533595 @default.
- W4386220290 cites W2929712475 @default.
- W4386220290 cites W2948352443 @default.
- W4386220290 cites W2953204260 @default.
- W4386220290 cites W2954262723 @default.
- W4386220290 cites W2963617422 @default.
- W4386220290 cites W2971899185 @default.
- W4386220290 cites W2972344703 @default.
- W4386220290 cites W2973461991 @default.
- W4386220290 cites W2998470023 @default.
- W4386220290 cites W2998583117 @default.
- W4386220290 cites W3009981184 @default.
- W4386220290 cites W3022214373 @default.
- W4386220290 cites W3089778110 @default.
- W4386220290 cites W3090072122 @default.
- W4386220290 cites W3094044834 @default.
- W4386220290 cites W3112358871 @default.
- W4386220290 cites W3122723190 @default.
- W4386220290 cites W3137590718 @default.
- W4386220290 cites W3161255713 @default.
- W4386220290 cites W3162809124 @default.
- W4386220290 cites W3172657955 @default.
- W4386220290 cites W3205646727 @default.