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- W4386221768 abstract "Abstract Key issues for research of COVID-19 pathogenesis are the lack of biopsies from patients and of samples at the onset of infection. To overcome these hurdles, hamsters were shown to be useful models for studying this disease. Here, we further leveraged the model to molecularly survey the disease progression from time-resolved single-cell RNA-sequencing data collected from healthy and SARS-CoV-2-infected Syrian and Roborovski hamster lungs. We compared our data to human COVID-19 studies, including BALF, nasal swab, and post-mortem lung tissue, and identified a shared axis of inflammation dominated by macrophages, neutrophils, and endothelial cells, which we show to be transient in Syrian and terminal in Roborovski hamsters. Our data suggest that, following SARS-CoV-2 infection, commitment to a type 1 or type 3-biased immunity determines moderate versus severe COVID-19 outcomes, respectively. One-Sentence Summary Activation of different immunological programs upon SARS-CoV-2 infection determines COVID-19 severity." @default.
- W4386221768 created "2023-08-29" @default.
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- W4386221768 date "2023-08-27" @default.
- W4386221768 modified "2023-10-02" @default.
- W4386221768 title "Single-cell-resolved interspecies comparison identifies a shared inflammatory axis and a dominant neutrophil-endothelial program in severe COVID-19" @default.
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- W4386221768 doi "https://doi.org/10.1101/2023.08.25.551434" @default.
- W4386221768 hasPublicationYear "2023" @default.
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