Matches in SemOpenAlex for { <https://semopenalex.org/work/W4386222511> ?p ?o ?g. }
Showing items 1 to 90 of
90
with 100 items per page.
- W4386222511 abstract "Understanding the interplay of different traits in a co-infection system with multiple strains has many applications in ecology and epidemiology. Because of high dimensionality and complex feedbacks between traits manifested in infection and co-infection, the study of such systems remains a challenge. In the case where strains are similar (quasi-neutrality assumption), we can model trait variation as perturbations in parameters, which simplifies analysis. Here, we apply singular perturbation theory to many strain parameters simultaneously, and advance analytically to obtain their explicit collective dynamics. We consider and study such a quasi-neutral model of susceptible-infected-susceptible (SIS) dynamics among N strains which vary in 5 fitness dimensions: transmissibility, clearance rate of single-and co-infection, transmission probability from mixed coinfection, and co-colonization vulnerability factors encompassing cooperation and competition. This quasi-neutral system is analyzed with a singular perturbation method through an appropriate slow-fast decomposition. The fast dynamics correspond to the embedded neutral system, while the slow dynamics are governed by an N-dimensional replicator equation, describing the time evolution of strain frequencies. The coefficients of this replicator system are pairwise invasion fitnesses between strains, which, in our model, are an explicit weighted sum of pairwise asymmetries along all trait dimensions. Remarkably these weights depend only on the parameters of the neutral system. Such model reduction highlights the centrality of the neutral system for dynamics at the edge of neutrality, and exposes critical features for maintenance of diversity." @default.
- W4386222511 created "2023-08-29" @default.
- W4386222511 creator A5020597399 @default.
- W4386222511 creator A5050693578 @default.
- W4386222511 creator A5066388017 @default.
- W4386222511 date "2021-04-15" @default.
- W4386222511 modified "2023-09-30" @default.
- W4386222511 title "Quasi-neutral Dynamics in a Coinfection System with N Strains and Asymmetries along Multiple Traits" @default.
- W4386222511 doi "https://doi.org/10.48550/arxiv.2104.07289" @default.
- W4386222511 hasPublicationYear "2021" @default.
- W4386222511 type Work @default.
- W4386222511 citedByCount "0" @default.
- W4386222511 crossrefType "posted-content" @default.
- W4386222511 hasAuthorship W4386222511A5020597399 @default.
- W4386222511 hasAuthorship W4386222511A5050693578 @default.
- W4386222511 hasAuthorship W4386222511A5066388017 @default.
- W4386222511 hasBestOaLocation W43862225111 @default.
- W4386222511 hasConcept C104317684 @default.
- W4386222511 hasConcept C105795698 @default.
- W4386222511 hasConcept C106934330 @default.
- W4386222511 hasConcept C111030470 @default.
- W4386222511 hasConcept C111472728 @default.
- W4386222511 hasConcept C121332964 @default.
- W4386222511 hasConcept C121864883 @default.
- W4386222511 hasConcept C138885662 @default.
- W4386222511 hasConcept C144024400 @default.
- W4386222511 hasConcept C149923435 @default.
- W4386222511 hasConcept C1570309 @default.
- W4386222511 hasConcept C16683452 @default.
- W4386222511 hasConcept C184898388 @default.
- W4386222511 hasConcept C186060115 @default.
- W4386222511 hasConcept C198394728 @default.
- W4386222511 hasConcept C199360897 @default.
- W4386222511 hasConcept C2522874641 @default.
- W4386222511 hasConcept C2777813720 @default.
- W4386222511 hasConcept C2779581858 @default.
- W4386222511 hasConcept C2908647359 @default.
- W4386222511 hasConcept C33923547 @default.
- W4386222511 hasConcept C41008148 @default.
- W4386222511 hasConcept C45799244 @default.
- W4386222511 hasConcept C50318809 @default.
- W4386222511 hasConcept C54355233 @default.
- W4386222511 hasConcept C62520636 @default.
- W4386222511 hasConcept C78458016 @default.
- W4386222511 hasConcept C86803240 @default.
- W4386222511 hasConceptScore W4386222511C104317684 @default.
- W4386222511 hasConceptScore W4386222511C105795698 @default.
- W4386222511 hasConceptScore W4386222511C106934330 @default.
- W4386222511 hasConceptScore W4386222511C111030470 @default.
- W4386222511 hasConceptScore W4386222511C111472728 @default.
- W4386222511 hasConceptScore W4386222511C121332964 @default.
- W4386222511 hasConceptScore W4386222511C121864883 @default.
- W4386222511 hasConceptScore W4386222511C138885662 @default.
- W4386222511 hasConceptScore W4386222511C144024400 @default.
- W4386222511 hasConceptScore W4386222511C149923435 @default.
- W4386222511 hasConceptScore W4386222511C1570309 @default.
- W4386222511 hasConceptScore W4386222511C16683452 @default.
- W4386222511 hasConceptScore W4386222511C184898388 @default.
- W4386222511 hasConceptScore W4386222511C186060115 @default.
- W4386222511 hasConceptScore W4386222511C198394728 @default.
- W4386222511 hasConceptScore W4386222511C199360897 @default.
- W4386222511 hasConceptScore W4386222511C2522874641 @default.
- W4386222511 hasConceptScore W4386222511C2777813720 @default.
- W4386222511 hasConceptScore W4386222511C2779581858 @default.
- W4386222511 hasConceptScore W4386222511C2908647359 @default.
- W4386222511 hasConceptScore W4386222511C33923547 @default.
- W4386222511 hasConceptScore W4386222511C41008148 @default.
- W4386222511 hasConceptScore W4386222511C45799244 @default.
- W4386222511 hasConceptScore W4386222511C50318809 @default.
- W4386222511 hasConceptScore W4386222511C54355233 @default.
- W4386222511 hasConceptScore W4386222511C62520636 @default.
- W4386222511 hasConceptScore W4386222511C78458016 @default.
- W4386222511 hasConceptScore W4386222511C86803240 @default.
- W4386222511 hasLocation W43862225111 @default.
- W4386222511 hasLocation W43862225112 @default.
- W4386222511 hasOpenAccess W4386222511 @default.
- W4386222511 hasPrimaryLocation W43862225111 @default.
- W4386222511 hasRelatedWork W2117359342 @default.
- W4386222511 hasRelatedWork W2155408399 @default.
- W4386222511 hasRelatedWork W2166775973 @default.
- W4386222511 hasRelatedWork W223778045 @default.
- W4386222511 hasRelatedWork W2804836960 @default.
- W4386222511 hasRelatedWork W3033828522 @default.
- W4386222511 hasRelatedWork W3158827286 @default.
- W4386222511 hasRelatedWork W4226262896 @default.
- W4386222511 hasRelatedWork W4231021975 @default.
- W4386222511 hasRelatedWork W4239778684 @default.
- W4386222511 isParatext "false" @default.
- W4386222511 isRetracted "false" @default.
- W4386222511 workType "article" @default.