Matches in SemOpenAlex for { <https://semopenalex.org/work/W4386225222> ?p ?o ?g. }
- W4386225222 abstract "Abstract Background: High mobility group box1 (HMGB1)is a chromatin-binding protein that especially regulates inflammatory signaling cascades. Several reports have demonstrated the anti-inflammatory effect of hesperidin. Whether hesperidin attenuates radiation-induced brain injury via inhibiting HMGB1-mediated neuroinflammation remains unclear. Methods: Morris water maze test and the step-down passive avoidance test were applied to evaluate whether hesperidin could relieve the irradiation-induced cognitive dysfunction. Nissl staining, western blotting and immunofluorescence were performed to uncover the mechanisms. Results: In this study, we found that radiation reduced the neuronal number and increased the content of the proinflammatory cytokines in the hippocampus, and hesperidin significantly reversed these changes. More importantly, hesperidin significantly improved the learning and memory abilities of X-ray-stimulated mice. We also found that radiation markedly increased Iba-1 expression in the hippocampus and resulted in substantial translocation of HMGB1 from the nucleus to the cytoplasm in the hippocampus and BV-2 cell, and hesperidin reversed the radiation-induced upregulation of Iba-1 and the cytoplasmic translocation of HMGB1. Moreover, hesperidin rescued the radiation-induced the upregulations in the phosphorylation levels of ERK, p38 and p65 in the hippocampus. Conclusions: This study demonstrated that hesperidin alleviated the radiation-induced cognitive dysfunction via inhibiting HMGB-mediated neuroinflammation, and indicated that hesperidin could be a promising candidate for treatment of radiation- induced brain injury." @default.
- W4386225222 created "2023-08-29" @default.
- W4386225222 creator A5016172715 @default.
- W4386225222 creator A5017459737 @default.
- W4386225222 creator A5026851189 @default.
- W4386225222 creator A5031993303 @default.
- W4386225222 creator A5055131613 @default.
- W4386225222 creator A5064204211 @default.
- W4386225222 creator A5086414181 @default.
- W4386225222 date "2023-08-28" @default.
- W4386225222 modified "2023-09-30" @default.
- W4386225222 title "Hesperidin relieves irradiation-induced cognitive dysfunction via regulation of HMGB1-mediated neuroinflammation" @default.
- W4386225222 cites W1253118376 @default.
- W4386225222 cites W1847744871 @default.
- W4386225222 cites W1988474257 @default.
- W4386225222 cites W2042407426 @default.
- W4386225222 cites W2615611572 @default.
- W4386225222 cites W2731965142 @default.
- W4386225222 cites W2752507303 @default.
- W4386225222 cites W2761267249 @default.
- W4386225222 cites W2772826139 @default.
- W4386225222 cites W2794073739 @default.
- W4386225222 cites W2871293796 @default.
- W4386225222 cites W2900871371 @default.
- W4386225222 cites W2922123514 @default.
- W4386225222 cites W2947540556 @default.
- W4386225222 cites W2967082433 @default.
- W4386225222 cites W3007246700 @default.
- W4386225222 cites W3008301007 @default.
- W4386225222 cites W3012314530 @default.
- W4386225222 cites W3012483466 @default.
- W4386225222 cites W3016355638 @default.
- W4386225222 cites W3021928953 @default.
- W4386225222 cites W3024402119 @default.
- W4386225222 cites W3026226739 @default.
- W4386225222 cites W3026531298 @default.
- W4386225222 cites W3033518321 @default.
- W4386225222 cites W3035563850 @default.
- W4386225222 cites W3040133850 @default.
- W4386225222 cites W3040339736 @default.
- W4386225222 cites W3081439759 @default.
- W4386225222 cites W4313368057 @default.
- W4386225222 cites W818915126 @default.
- W4386225222 doi "https://doi.org/10.21203/rs.3.rs-3284325/v1" @default.
- W4386225222 hasPublicationYear "2023" @default.
- W4386225222 type Work @default.
- W4386225222 citedByCount "0" @default.
- W4386225222 crossrefType "posted-content" @default.
- W4386225222 hasAuthorship W4386225222A5016172715 @default.
- W4386225222 hasAuthorship W4386225222A5017459737 @default.
- W4386225222 hasAuthorship W4386225222A5026851189 @default.
- W4386225222 hasAuthorship W4386225222A5031993303 @default.
- W4386225222 hasAuthorship W4386225222A5055131613 @default.
- W4386225222 hasAuthorship W4386225222A5064204211 @default.
- W4386225222 hasAuthorship W4386225222A5086414181 @default.
- W4386225222 hasBestOaLocation W43862252221 @default.
- W4386225222 hasConcept C104317684 @default.
- W4386225222 hasConcept C126322002 @default.
- W4386225222 hasConcept C142724271 @default.
- W4386225222 hasConcept C164027704 @default.
- W4386225222 hasConcept C185592680 @default.
- W4386225222 hasConcept C204787440 @default.
- W4386225222 hasConcept C2776128092 @default.
- W4386225222 hasConcept C2776415932 @default.
- W4386225222 hasConcept C2776914184 @default.
- W4386225222 hasConcept C2780545709 @default.
- W4386225222 hasConcept C2781161787 @default.
- W4386225222 hasConcept C44752575 @default.
- W4386225222 hasConcept C55493867 @default.
- W4386225222 hasConcept C71924100 @default.
- W4386225222 hasConcept C87753298 @default.
- W4386225222 hasConcept C98274493 @default.
- W4386225222 hasConceptScore W4386225222C104317684 @default.
- W4386225222 hasConceptScore W4386225222C126322002 @default.
- W4386225222 hasConceptScore W4386225222C142724271 @default.
- W4386225222 hasConceptScore W4386225222C164027704 @default.
- W4386225222 hasConceptScore W4386225222C185592680 @default.
- W4386225222 hasConceptScore W4386225222C204787440 @default.
- W4386225222 hasConceptScore W4386225222C2776128092 @default.
- W4386225222 hasConceptScore W4386225222C2776415932 @default.
- W4386225222 hasConceptScore W4386225222C2776914184 @default.
- W4386225222 hasConceptScore W4386225222C2780545709 @default.
- W4386225222 hasConceptScore W4386225222C2781161787 @default.
- W4386225222 hasConceptScore W4386225222C44752575 @default.
- W4386225222 hasConceptScore W4386225222C55493867 @default.
- W4386225222 hasConceptScore W4386225222C71924100 @default.
- W4386225222 hasConceptScore W4386225222C87753298 @default.
- W4386225222 hasConceptScore W4386225222C98274493 @default.
- W4386225222 hasLocation W43862252221 @default.
- W4386225222 hasOpenAccess W4386225222 @default.
- W4386225222 hasPrimaryLocation W43862252221 @default.
- W4386225222 hasRelatedWork W2018239217 @default.
- W4386225222 hasRelatedWork W2026807204 @default.
- W4386225222 hasRelatedWork W2092272732 @default.
- W4386225222 hasRelatedWork W2366662520 @default.
- W4386225222 hasRelatedWork W2885111372 @default.
- W4386225222 hasRelatedWork W3022833040 @default.
- W4386225222 hasRelatedWork W3169791660 @default.
- W4386225222 hasRelatedWork W4200607734 @default.
- W4386225222 hasRelatedWork W4319724936 @default.