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- W4386225754 abstract "The retinoblastoma protein (RB)-mediated regulation of E2F is a component of a highly conserved cell cycle machine. However, RB's tumor suppressor activity, like RB's requirement in animal development, is tissue-specific, context-specific, and sometimes appears uncoupled from cell proliferation. Detailed new information about RB's genomic distribution provides a new perspective on the complexity of RB function, suggesting that some of its functional specificity results from context-specific RB association with chromatin. Here we summarize recent evidence showing that RB targets different types of chromatin regulatory elements at different cell cycle stages. RB controls traditional RB/E2F targets prior to S-phase, but, when cells proliferate, RB redistributes to cell type-specific chromatin loci. We discuss the broad implications of the new data for RB research." @default.
- W4386225754 created "2023-08-29" @default.
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- W4386225754 date "2023-08-01" @default.
- W4386225754 modified "2023-09-28" @default.
- W4386225754 title "Patterns in the tapestry of chromatin-bound RB" @default.
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- W4386225754 doi "https://doi.org/10.1016/j.tcb.2023.07.012" @default.
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