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• W4386226637 endingPage "123355" @default.
• W4386226637 startingPage "123355" @default.
• W4386226637 abstract "The pharmaceutical industry has traditionally manufactured medicines in a limited range of dose strengths, with an emphasis on addressing the needs of the largest patient subgroups. This has disadvantaged smaller patient subsets, such as children, who often cannot find drug products in dosage levels suitable for their requirements. In recent years, development of pharmaceutical mini-tablets has emerged as an attractive solution to this problem. These are small-size dosages that offer attractive features such as flexible and personalized drug dosing, ease of swallowing, and tailored drug release, making them an excellent choice for administering medicines to children. This study presents a novel technique for manufacturing pharmaceutical mini-tablets, using a drop-on-demand (DoD) printing system. In this method, a DoD system is used to generate precise droplets of a melt-based formulation, which are then captured and solidified in an inert solvent bath to produce individual mini-tablets. The study also evaluates the performance of this technique for various formulations, and quantifies two critical quality attributes (CQAs) of the resulting mini-tablets: content uniformity and dissolution behavior. The findings demonstrate that the manufactured mini-tablets can meet regulatory specifications for both CQAs, and that their release profiles can be customized by modifying the excipients used. The study also discusses promising areas of application and limitations of this technique." @default.
• W4386226637 created "2023-08-29" @default.
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• W4386226637 date "2023-09-01" @default.
• W4386226637 modified "2023-10-16" @default.
• W4386226637 title "Manufacturing pharmaceutical mini-tablets for pediatric patients using drop-on-demand printing" @default.
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• W4386226637 doi "https://doi.org/10.1016/j.ijpharm.2023.123355" @default.
• W4386226637 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37647980" @default.
• W4386226637 hasPublicationYear "2023" @default.
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