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• W4386227009 endingPage "110690" @default.
• W4386227009 startingPage "110690" @default.
• W4386227009 abstract "Imidacloprid (IMID) is one of the most widely used neonicotinoid insecticides globally and, consequently, a probable widespread environmental contaminant. The potential neurotoxic effects of IMID have been previously reported. This study aimed to investigate the possible beneficial effect of thymol (TML) in relieving IMID-induced harmful effects on the brain of male Sprague-Dawley rats. For this aim, four groups (10 rats/group) were orally administered corn oil, TML (30 mg/kg b.wt), IMID (22.5 mg/kg b.wt), or TML + IMID for 56 days. The brain tissues were biochemically, histopathologically, and immunohistochemically evaluated. The results displayed that TML significantly restored the IMID-induced depletion of the total antioxidant capacity of the brain tissues. At the same time, the IMID-associated increased levels of lipid peroxidation in terms of malondialdehyde content were markedly suppressed in the TML + IMID group. Also, TML oral dosing markedly reduced the release of inflammatory elements, including nitric oxide and myeloperoxidase, resulting from IMID exposure. Furthermore, the IMID-induced decrease in gamma-aminobutyric acid but the increase in acetylcholinesterase was considerably reversed by TML oral dosing. Additionally, TML oral administration significantly counteracted the IMID-induced hepatic DNA damage, as revealed by the comet assay. Besides, a significant downregulation in hepatic Caspase-3 was evident in the TML + IMID group compared to the IMID group. However, TML oral dosing has not significantly altered the IMID-induced nuclear factor (NF-κB p65) increase. Therefore, TML could be a protective agent against IMID-induced detrimental impacts on brain tissue, possibly through its antioxidant, antiapoptotic, and anti-inflammatory activities." @default.
• W4386227009 created "2023-08-29" @default.
• W4386227009 creator A5010696083 @default.
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• W4386227009 date "2023-09-01" @default.
• W4386227009 modified "2023-09-26" @default.
• W4386227009 title "Thymol abates the detrimental impacts of imidacloprid on rat brains by lessening oxidative damage and apoptotic and inflammatory reactions" @default.
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• W4386227009 doi "https://doi.org/10.1016/j.cbi.2023.110690" @default.
• W4386227009 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37648049" @default.
• W4386227009 hasPublicationYear "2023" @default.
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