FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4386232512> ?p ?o ?g. }

• W4386232512 endingPage "115379" @default.
• W4386232512 startingPage "115379" @default.
• W4386232512 abstract "Nonalcoholic steatohepatitis (NASH) is a progressive fibrotic disease associated with an increased risk of developing hepatocellular carcinoma; at present, no efficient therapeutic strategy has been established. Herein, we examined the efficacy of PRI-724, a potent inhibitor of CBP/β-catenin signaling, for treating NASH-related liver fibrosis and disorder and characterized its mechanism. Choline-deficient, L-amino acid-defined, high-fat diet (CDAHFD)-fed mice exhibited NASH-induced liver fibrosis that is characterized by steatosis, lobular inflammation, hepatocellular injury and collagen fibrils. To examine the therapeutic effect, CDAHFD-fed mice were administered PRI-724. Serum levels of ALT and pro-fibrotic molecule, i.e. Mac-2 bp, alpha smooth muscle actin, type I and type III collagens, decreased significantly. mRNA levels of the matrix metalloproteinases Mmp8 and Mmp9 in the liver were significantly increased, and increases in the abundance of MMP9-producing neutrophils and macrophages were observed. Marco+Mmp9+Cd68+ Kupffer cells were only observed in the livers of mice treated with PRI-724, and Mmp9 expression in Marco+Cd68+ Kupffer cells increased 4.3-fold. Moreover, hepatic expression of the lipid metabolism regulator, pyruvate dehydrogenase kinase 4 and liver lipid droplets also decreased significantly. PRI-724-treated NASH mice not only recovered from NASH-related liver fibrosis through the effect of PRI-724 down-regulating the expression of pro-fibrotic genes and up-regulating the expression of anti-fibrotic genes, but they also recovered from NASH-induced liver disorder. PRI-724, a selective CBP/β-catenin inhibitor, thus shows a potent therapeutic effect for NASH-related liver fibrosis and for decreasing adipose tissue in the liver." @default.
• W4386232512 created "2023-08-29" @default.
• W4386232512 creator A5008182946 @default.
• W4386232512 creator A5008377317 @default.
• W4386232512 creator A5017078328 @default.
• W4386232512 creator A5020825623 @default.
• W4386232512 creator A5022430910 @default.
• W4386232512 creator A5029649651 @default.
• W4386232512 creator A5034336730 @default.
• W4386232512 creator A5037981058 @default.
• W4386232512 creator A5039611077 @default.
• W4386232512 creator A5048187734 @default.
• W4386232512 creator A5063055403 @default.
• W4386232512 creator A5070328318 @default.
• W4386232512 creator A5074640028 @default.
• W4386232512 creator A5077381752 @default.
• W4386232512 creator A5089562604 @default.
• W4386232512 creator A5092812394 @default.
• W4386232512 date "2023-10-01" @default.
• W4386232512 modified "2023-10-14" @default.
• W4386232512 title "Molecular insights of a CBP/β-catenin-signaling inhibitor on nonalcoholic steatohepatitis-induced liver fibrosis and disorder" @default.
• W4386232512 cites W1846286601 @default.
• W4386232512 cites W1964572117 @default.
• W4386232512 cites W1992240317 @default.
• W4386232512 cites W1993600822 @default.
• W4386232512 cites W2022273281 @default.
• W4386232512 cites W2041771597 @default.
• W4386232512 cites W2059613020 @default.
• W4386232512 cites W2063437798 @default.
• W4386232512 cites W2098555833 @default.
• W4386232512 cites W2133035501 @default.
• W4386232512 cites W2161413382 @default.
• W4386232512 cites W2162382402 @default.
• W4386232512 cites W2167446786 @default.
• W4386232512 cites W2332784463 @default.
• W4386232512 cites W2418111900 @default.
• W4386232512 cites W2519072301 @default.
• W4386232512 cites W2595541755 @default.
• W4386232512 cites W2731411640 @default.
• W4386232512 cites W2743667261 @default.
• W4386232512 cites W2755910736 @default.
• W4386232512 cites W2759997926 @default.
• W4386232512 cites W2766220228 @default.
• W4386232512 cites W2767674938 @default.
• W4386232512 cites W2794480084 @default.
• W4386232512 cites W2896518632 @default.
• W4386232512 cites W2905319503 @default.
• W4386232512 cites W2910914574 @default.
• W4386232512 cites W2936817332 @default.
• W4386232512 cites W2941033601 @default.
• W4386232512 cites W2944563907 @default.
• W4386232512 cites W2961663205 @default.
• W4386232512 cites W2969422528 @default.
• W4386232512 cites W2979595830 @default.
• W4386232512 cites W3035987524 @default.
• W4386232512 cites W3083195565 @default.
• W4386232512 cites W3084955164 @default.
• W4386232512 cites W3113231317 @default.
• W4386232512 cites W3118981406 @default.
• W4386232512 cites W3160603270 @default.
• W4386232512 cites W4210666233 @default.
• W4386232512 cites W4241489351 @default.
• W4386232512 cites W4247053599 @default.
• W4386232512 cites W4280573773 @default.
• W4386232512 cites W4310169490 @default.
• W4386232512 doi "https://doi.org/10.1016/j.biopha.2023.115379" @default.
• W4386232512 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37647690" @default.
• W4386232512 hasPublicationYear "2023" @default.
• W4386232512 type Work @default.
• W4386232512 citedByCount "0" @default.
• W4386232512 crossrefType "journal-article" @default.
• W4386232512 hasAuthorship W4386232512A5008182946 @default.
• W4386232512 hasAuthorship W4386232512A5008377317 @default.
• W4386232512 hasAuthorship W4386232512A5017078328 @default.
• W4386232512 hasAuthorship W4386232512A5020825623 @default.
• W4386232512 hasAuthorship W4386232512A5022430910 @default.
• W4386232512 hasAuthorship W4386232512A5029649651 @default.
• W4386232512 hasAuthorship W4386232512A5034336730 @default.
• W4386232512 hasAuthorship W4386232512A5037981058 @default.
• W4386232512 hasAuthorship W4386232512A5039611077 @default.
• W4386232512 hasAuthorship W4386232512A5048187734 @default.
• W4386232512 hasAuthorship W4386232512A5063055403 @default.
• W4386232512 hasAuthorship W4386232512A5070328318 @default.
• W4386232512 hasAuthorship W4386232512A5074640028 @default.
• W4386232512 hasAuthorship W4386232512A5077381752 @default.
• W4386232512 hasAuthorship W4386232512A5089562604 @default.
• W4386232512 hasAuthorship W4386232512A5092812394 @default.
• W4386232512 hasBestOaLocation W43862325121 @default.
• W4386232512 hasConcept C104317684 @default.
• W4386232512 hasConcept C126322002 @default.
• W4386232512 hasConcept C127561419 @default.
• W4386232512 hasConcept C134018914 @default.
• W4386232512 hasConcept C185592680 @default.
• W4386232512 hasConcept C204232928 @default.
• W4386232512 hasConcept C2775997469 @default.
• W4386232512 hasConcept C2776175330 @default.
• W4386232512 hasConcept C2776460901 @default.
• W4386232512 hasConcept C2776954865 @default.

• next