Matches in SemOpenAlex for { <https://semopenalex.org/work/W4386240986> ?p ?o ?g. }
- W4386240986 abstract "Abstract The direct catalytic asymmetric hydrogenation of pyridines for the synthesis of piperidines remains a challenge. Herein, we report a one‐pot asymmetric hydrogenation of pyridines with subsequent N‐alkylation using a traceless Brønsted acid activation strategy. Catalyzed by an iridium‐BINAP complex, the substrates undergo ketone reduction, cyclization and pyridine hydrogenation in sequence to form indolizidines and quinolizidines. The absolute configuration of the stereocenter of the alcohol is retained and influences the formation of the second stereocenter. Experimental and theoretical mechanistic studies reveal that the chloride anion and certain noncovalent interactions govern the stereoselectivity of the cascade reaction throughout the catalytic process." @default.
- W4386240986 created "2023-08-30" @default.
- W4386240986 creator A5001954537 @default.
- W4386240986 creator A5002367443 @default.
- W4386240986 creator A5019055174 @default.
- W4386240986 creator A5045793387 @default.
- W4386240986 creator A5052988638 @default.
- W4386240986 creator A5070695078 @default.
- W4386240986 creator A5071235043 @default.
- W4386240986 date "2023-09-06" @default.
- W4386240986 modified "2023-10-05" @default.
- W4386240986 title "An Asymmetric Hydrogenation/N‐Alkylation Sequence for a Step‐Economical Route to Indolizidines and Quinolizidines" @default.
- W4386240986 cites W180105277 @default.
- W4386240986 cites W1964626418 @default.
- W4386240986 cites W1965435179 @default.
- W4386240986 cites W1976114099 @default.
- W4386240986 cites W1986619551 @default.
- W4386240986 cites W1995022283 @default.
- W4386240986 cites W1999556799 @default.
- W4386240986 cites W2009884940 @default.
- W4386240986 cites W2018014134 @default.
- W4386240986 cites W2022601800 @default.
- W4386240986 cites W2023376917 @default.
- W4386240986 cites W2025207174 @default.
- W4386240986 cites W2043973654 @default.
- W4386240986 cites W2069336075 @default.
- W4386240986 cites W2084616510 @default.
- W4386240986 cites W2103632989 @default.
- W4386240986 cites W2134019393 @default.
- W4386240986 cites W2134764589 @default.
- W4386240986 cites W2136708938 @default.
- W4386240986 cites W2146081115 @default.
- W4386240986 cites W2147133423 @default.
- W4386240986 cites W2169146772 @default.
- W4386240986 cites W2169571664 @default.
- W4386240986 cites W2277980090 @default.
- W4386240986 cites W2288997550 @default.
- W4386240986 cites W2306594941 @default.
- W4386240986 cites W2316048038 @default.
- W4386240986 cites W2317236511 @default.
- W4386240986 cites W2323050751 @default.
- W4386240986 cites W2325394883 @default.
- W4386240986 cites W2331429153 @default.
- W4386240986 cites W2332566082 @default.
- W4386240986 cites W2332799615 @default.
- W4386240986 cites W2469619836 @default.
- W4386240986 cites W2558550419 @default.
- W4386240986 cites W2561599074 @default.
- W4386240986 cites W2599634799 @default.
- W4386240986 cites W2601109746 @default.
- W4386240986 cites W2602423580 @default.
- W4386240986 cites W2751087354 @default.
- W4386240986 cites W2782206952 @default.
- W4386240986 cites W2783137249 @default.
- W4386240986 cites W2788064551 @default.
- W4386240986 cites W2791948131 @default.
- W4386240986 cites W2888431137 @default.
- W4386240986 cites W2904983984 @default.
- W4386240986 cites W2906211192 @default.
- W4386240986 cites W2913761448 @default.
- W4386240986 cites W2921540193 @default.
- W4386240986 cites W2952144746 @default.
- W4386240986 cites W2953080789 @default.
- W4386240986 cites W2982161494 @default.
- W4386240986 cites W3003423641 @default.
- W4386240986 cites W3006550406 @default.
- W4386240986 cites W3007783595 @default.
- W4386240986 cites W3008164504 @default.
- W4386240986 cites W3021812414 @default.
- W4386240986 cites W3046985778 @default.
- W4386240986 cites W3072286746 @default.
- W4386240986 cites W3082135974 @default.
- W4386240986 cites W3102337801 @default.
- W4386240986 cites W3111193707 @default.
- W4386240986 cites W3144592352 @default.
- W4386240986 cites W3181394781 @default.
- W4386240986 cites W3197146727 @default.
- W4386240986 cites W3208795778 @default.
- W4386240986 cites W3208858489 @default.
- W4386240986 cites W4205629284 @default.
- W4386240986 cites W4206957761 @default.
- W4386240986 cites W4211259730 @default.
- W4386240986 cites W4220821532 @default.
- W4386240986 cites W4241321845 @default.
- W4386240986 cites W4281885601 @default.
- W4386240986 cites W4282009101 @default.
- W4386240986 cites W4371646293 @default.
- W4386240986 doi "https://doi.org/10.1002/ange.202308836" @default.
- W4386240986 hasPublicationYear "2023" @default.
- W4386240986 type Work @default.
- W4386240986 citedByCount "0" @default.
- W4386240986 crossrefType "journal-article" @default.
- W4386240986 hasAuthorship W4386240986A5001954537 @default.
- W4386240986 hasAuthorship W4386240986A5002367443 @default.
- W4386240986 hasAuthorship W4386240986A5019055174 @default.
- W4386240986 hasAuthorship W4386240986A5045793387 @default.
- W4386240986 hasAuthorship W4386240986A5052988638 @default.
- W4386240986 hasAuthorship W4386240986A5070695078 @default.
- W4386240986 hasAuthorship W4386240986A5071235043 @default.
- W4386240986 hasConcept C134195300 @default.