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- W4386241090 abstract "Abstract The exploration of neural circuitry is essential for understanding the computational mechanisms and physiology of the brain. Despite significant advances in materials and fabrication techniques, controlling neuronal connectivity and response in three dimensions continues to present a formidable challenge. Here, we present a method for engineering the growth of three-dimensional (3D) neural circuits with the capability for optical stimulation. We fabricated bioactive interfaces by melt electrospinning writing (MEW) of 3D printed polycaprolactone (PCL) scaffolds followed by coating with titanium carbide (Ti 3 C 2 T x MXene). Beyond enhancing hydrophilicity, cell adhesion, and electrical conductivity, the Ti 3 C 2 T x MXene coating enabled optocapacitance-based neuronal stimulation due to illumination-induced local temperature increases. This work presents a strategy for additive manufacturing of neural tissues with optical control for functional tissue engineering and neural circuit computation." @default.
- W4386241090 created "2023-08-30" @default.
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- W4386241090 date "2023-08-29" @default.
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- W4386241090 title "3D Printed Ti3C2Tx MXene/PCL Scaffolds for Guided Neuronal Growth and Photothermal Stimulation" @default.
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- W4386241090 doi "https://doi.org/10.1101/2023.08.28.555002" @default.
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