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• W4386244013 abstract "Abstract Background Secondary findings (SFs) in comprehensive genomic profiling (CGP) testing can affect not only the healthcare of cancer patients but also their first-degree relatives. To date, however, the preferences of first-degree relatives concerning the disclosure of SFs have been not elucidated compared to that of cancer patients. Methods We retrospectively investigated the preferences of adult patients who underwent CGP tests and their adult first-degree relatives. Main outcomes were (i) the proportion of patients and first-degree relatives who expressed their preference before the results of CGP tests were disclosed; and (ii) the proportion of patients and first-degree relatives who opted for disclosure of SFs. Results Seventy-three patients and 252 first-degree relatives were included. All patients had expressed their preference, and all patients except one opted for disclosure. In contrast, only 41% of the 252 first-degree relatives expressed a preference prior to disclosure: 34% opted for disclosure and 7% refused disclosure. On multivariate analysis, the failure of first-degree relatives to express a preference was associated with old age and absence from pre-test explanatory sessions at the cancer genome clinic. All patients received a pre-test explanation from health professionals; in contrast, only 8% of first-degree relatives received an explanation from health professionals, while a further 35% of first-degree relatives received an explanation from the patient and 36% receive no pre-test explanation of SFs at all. Conclusion Our study highlights the difficulty of respecting the autonomy of individual first-degree relatives, particularly for those who do not attend pre-test explanatory sessions or are elderly." @default.
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• W4386244013 date "2023-08-29" @default.
• W4386244013 modified "2023-09-27" @default.
• W4386244013 title "Expression of preference for the disclosure of secondary findings of comprehensive genomic profiling tests by cancer patients and relatives" @default.
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• W4386244013 doi "https://doi.org/10.21203/rs.3.rs-3266046/v1" @default.
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