Matches in SemOpenAlex for { <https://semopenalex.org/work/W4386244599> ?p ?o ?g. }
Showing items 1 to 98 of
98
with 100 items per page.
- W4386244599 abstract "Lysosomes are critical in modulating the progression and metastasis for various cancers. There is currently an unmet need for lysosomal alkalizers that can selectively and safely alter the pH and inhibit the function of cancer lysosomes. Here we report an effective, selective, and safe lysosomal alkalizer that can inhibit autophagy and suppress tumors in mice. Our lysosomal alkalizer consists of an Fex Oy core that generates hydroxyl radicals (•OH) in the presence of excessive H+ and H2 O2 inside cancer lysosomes and CeO2-z satellites that capture and convert •OH into hydroxide ions (OH- ). Alkalized lysosomes, which display impaired enzyme activity and autophagy, lead to cancer cell apoptosis. We show that our alkalizer effectively inhibited both local and systemic tumor growth and metastasis in mice. Our work demonstrates that the intrinsic properties of nanoparticles can be harnessed to build effective lysosomal alkalizers that are both selective and safe. This article is protected by copyright. All rights reserved." @default.
- W4386244599 created "2023-08-30" @default.
- W4386244599 creator A5013697180 @default.
- W4386244599 creator A5015306310 @default.
- W4386244599 creator A5018744849 @default.
- W4386244599 creator A5025901845 @default.
- W4386244599 creator A5029003093 @default.
- W4386244599 creator A5032658931 @default.
- W4386244599 creator A5037471217 @default.
- W4386244599 creator A5038752179 @default.
- W4386244599 creator A5048329149 @default.
- W4386244599 creator A5054158563 @default.
- W4386244599 creator A5058085020 @default.
- W4386244599 creator A5059269081 @default.
- W4386244599 creator A5068400813 @default.
- W4386244599 creator A5069772530 @default.
- W4386244599 creator A5073636083 @default.
- W4386244599 creator A5077442619 @default.
- W4386244599 creator A5078473635 @default.
- W4386244599 creator A5087000163 @default.
- W4386244599 creator A5089545632 @default.
- W4386244599 creator A5091572776 @default.
- W4386244599 date "2023-08-29" @default.
- W4386244599 modified "2023-10-11" @default.
- W4386244599 title "Cascade Catalytic Nanoparticles Selectively Alkalize Cancerous Lysosomes to Suppress Cancer Progression And Metastasis" @default.
- W4386244599 doi "https://doi.org/10.1002/adma.202305394" @default.
- W4386244599 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37643367" @default.
- W4386244599 hasPublicationYear "2023" @default.
- W4386244599 type Work @default.
- W4386244599 citedByCount "0" @default.
- W4386244599 crossrefType "journal-article" @default.
- W4386244599 hasAuthorship W4386244599A5013697180 @default.
- W4386244599 hasAuthorship W4386244599A5015306310 @default.
- W4386244599 hasAuthorship W4386244599A5018744849 @default.
- W4386244599 hasAuthorship W4386244599A5025901845 @default.
- W4386244599 hasAuthorship W4386244599A5029003093 @default.
- W4386244599 hasAuthorship W4386244599A5032658931 @default.
- W4386244599 hasAuthorship W4386244599A5037471217 @default.
- W4386244599 hasAuthorship W4386244599A5038752179 @default.
- W4386244599 hasAuthorship W4386244599A5048329149 @default.
- W4386244599 hasAuthorship W4386244599A5054158563 @default.
- W4386244599 hasAuthorship W4386244599A5058085020 @default.
- W4386244599 hasAuthorship W4386244599A5059269081 @default.
- W4386244599 hasAuthorship W4386244599A5068400813 @default.
- W4386244599 hasAuthorship W4386244599A5069772530 @default.
- W4386244599 hasAuthorship W4386244599A5073636083 @default.
- W4386244599 hasAuthorship W4386244599A5077442619 @default.
- W4386244599 hasAuthorship W4386244599A5078473635 @default.
- W4386244599 hasAuthorship W4386244599A5087000163 @default.
- W4386244599 hasAuthorship W4386244599A5089545632 @default.
- W4386244599 hasAuthorship W4386244599A5091572776 @default.
- W4386244599 hasConcept C121608353 @default.
- W4386244599 hasConcept C12554922 @default.
- W4386244599 hasConcept C181199279 @default.
- W4386244599 hasConcept C185592680 @default.
- W4386244599 hasConcept C190283241 @default.
- W4386244599 hasConcept C192562407 @default.
- W4386244599 hasConcept C203522944 @default.
- W4386244599 hasConcept C2779013556 @default.
- W4386244599 hasConcept C2780216420 @default.
- W4386244599 hasConcept C502942594 @default.
- W4386244599 hasConcept C54355233 @default.
- W4386244599 hasConcept C55493867 @default.
- W4386244599 hasConcept C86803240 @default.
- W4386244599 hasConcept C95444343 @default.
- W4386244599 hasConcept C96232424 @default.
- W4386244599 hasConceptScore W4386244599C121608353 @default.
- W4386244599 hasConceptScore W4386244599C12554922 @default.
- W4386244599 hasConceptScore W4386244599C181199279 @default.
- W4386244599 hasConceptScore W4386244599C185592680 @default.
- W4386244599 hasConceptScore W4386244599C190283241 @default.
- W4386244599 hasConceptScore W4386244599C192562407 @default.
- W4386244599 hasConceptScore W4386244599C203522944 @default.
- W4386244599 hasConceptScore W4386244599C2779013556 @default.
- W4386244599 hasConceptScore W4386244599C2780216420 @default.
- W4386244599 hasConceptScore W4386244599C502942594 @default.
- W4386244599 hasConceptScore W4386244599C54355233 @default.
- W4386244599 hasConceptScore W4386244599C55493867 @default.
- W4386244599 hasConceptScore W4386244599C86803240 @default.
- W4386244599 hasConceptScore W4386244599C95444343 @default.
- W4386244599 hasConceptScore W4386244599C96232424 @default.
- W4386244599 hasLocation W43862445991 @default.
- W4386244599 hasLocation W43862445992 @default.
- W4386244599 hasOpenAccess W4386244599 @default.
- W4386244599 hasPrimaryLocation W43862445991 @default.
- W4386244599 hasRelatedWork W2010050523 @default.
- W4386244599 hasRelatedWork W2024105361 @default.
- W4386244599 hasRelatedWork W2042046776 @default.
- W4386244599 hasRelatedWork W2160991795 @default.
- W4386244599 hasRelatedWork W2234636301 @default.
- W4386244599 hasRelatedWork W2464503524 @default.
- W4386244599 hasRelatedWork W2580657578 @default.
- W4386244599 hasRelatedWork W3208697890 @default.
- W4386244599 hasRelatedWork W4283822279 @default.
- W4386244599 hasRelatedWork W4304116770 @default.
- W4386244599 isParatext "false" @default.
- W4386244599 isRetracted "false" @default.
- W4386244599 workType "article" @default.