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- W4386244910 abstract "Aim: To discuss the progress of extracellular matrix (ECM) characteristics, mitochondrial homeostasis, and their potential crosstalk in the pathogenesis of sarcopenia, a geriatric syndrome characterized by a generalized and progressive reduction in muscle mass, strength, and physical performance.Methods: This review focuses on the anatomy and physiology of skeletal muscle, alterations of ECM and mitochondria during ageing, and the role of the interplay between ECM and mitochondria in the pathogenesis of sarcopenia.Results: Emerging evidence points to a clear interplay between mitochondria and ECM in various tissues and organs. Under the ageing process, the ECM undergoes changes in composition and physical properties that may mediate mitochondrial changes via the systematic metabolism, ROS, SPARC pathway, and AMPK/PGC-1α signalling, which in turn exacerbate muscle degeneration. However, the precise effects of such crosstalk on the pathobiology of ageing, particularly in skeletal muscle, have not yet been fully understood.Conclusion: The changes in skeletal muscle ECM and mitochondria are partially responsible for the worsened muscle function during the ageing process. A deeper understanding of their alterations and interactions in sarcopenic patients can help prevent sarcopenia and improve its prognoses.Sarcopenia is a senile syndrome featured by a progressive and generalized decline of muscle mass, strength, and physical performance. Given the complexity and importance of the extracellular matrix (ECM) and mitochondria of skeletal muscle, we, in this review, summarized current progress in the alterations of ECM properties and mitochondrial homeostasis in aged skeletal muscle, and have found several potential links between them. And we believe that this work could provide new insight into the prevention and treatment of age-related sarcopenia." @default.
- W4386244910 created "2023-08-30" @default.
- W4386244910 creator A5017852749 @default.
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- W4386244910 creator A5087322749 @default.
- W4386244910 date "2023-08-29" @default.
- W4386244910 modified "2023-10-14" @default.
- W4386244910 title "Ageing of skeletal muscle extracellular matrix and mitochondria: finding a potential link" @default.
- W4386244910 cites W1500436940 @default.
- W4386244910 cites W1502614187 @default.
- W4386244910 cites W1512819323 @default.
- W4386244910 cites W1543036842 @default.
- W4386244910 cites W1682269205 @default.
- W4386244910 cites W1693278100 @default.
- W4386244910 cites W1766184155 @default.
- W4386244910 cites W189679146 @default.
- W4386244910 cites W1903090781 @default.
- W4386244910 cites W1915485606 @default.
- W4386244910 cites W1948159539 @default.
- W4386244910 cites W1965470471 @default.
- W4386244910 cites W1965761285 @default.
- W4386244910 cites W1966078541 @default.
- W4386244910 cites W197462632 @default.
- W4386244910 cites W1977548231 @default.
- W4386244910 cites W1978903047 @default.
- W4386244910 cites W1981831271 @default.
- W4386244910 cites W1982723225 @default.
- W4386244910 cites W1988233683 @default.
- W4386244910 cites W1989026904 @default.
- W4386244910 cites W1993476327 @default.
- W4386244910 cites W1993635951 @default.
- W4386244910 cites W1993977580 @default.
- W4386244910 cites W1995527023 @default.
- W4386244910 cites W1997010780 @default.
- W4386244910 cites W1999218428 @default.
- W4386244910 cites W1999655515 @default.
- W4386244910 cites W2000723048 @default.
- W4386244910 cites W2001061424 @default.
- W4386244910 cites W2003125782 @default.
- W4386244910 cites W2007546912 @default.
- W4386244910 cites W2008330573 @default.
- W4386244910 cites W2013804384 @default.
- W4386244910 cites W2017011351 @default.
- W4386244910 cites W2017075649 @default.
- W4386244910 cites W2024013299 @default.
- W4386244910 cites W2025945246 @default.
- W4386244910 cites W2025957803 @default.
- W4386244910 cites W2026069493 @default.
- W4386244910 cites W2028722077 @default.
- W4386244910 cites W2031636157 @default.
- W4386244910 cites W2033932699 @default.
- W4386244910 cites W2036787961 @default.
- W4386244910 cites W2036898624 @default.
- W4386244910 cites W2040546082 @default.
- W4386244910 cites W2044144438 @default.
- W4386244910 cites W2045776501 @default.
- W4386244910 cites W2049452651 @default.
- W4386244910 cites W2051434891 @default.
- W4386244910 cites W2051546365 @default.
- W4386244910 cites W2052008941 @default.
- W4386244910 cites W2053947428 @default.
- W4386244910 cites W2054511417 @default.
- W4386244910 cites W2054523950 @default.
- W4386244910 cites W2057072817 @default.
- W4386244910 cites W2062796073 @default.
- W4386244910 cites W2063301281 @default.
- W4386244910 cites W2064230441 @default.
- W4386244910 cites W2066016132 @default.
- W4386244910 cites W2070254527 @default.
- W4386244910 cites W2070459088 @default.
- W4386244910 cites W2075303668 @default.
- W4386244910 cites W2076598575 @default.
- W4386244910 cites W2079233330 @default.
- W4386244910 cites W2093224967 @default.
- W4386244910 cites W2094304792 @default.
- W4386244910 cites W2096668802 @default.
- W4386244910 cites W2101232589 @default.
- W4386244910 cites W2106504494 @default.
- W4386244910 cites W2109017400 @default.
- W4386244910 cites W2109995938 @default.
- W4386244910 cites W2112299930 @default.
- W4386244910 cites W2115438428 @default.
- W4386244910 cites W2118008234 @default.
- W4386244910 cites W2119792393 @default.
- W4386244910 cites W2121198137 @default.
- W4386244910 cites W2121486568 @default.
- W4386244910 cites W2124153237 @default.
- W4386244910 cites W2124821727 @default.
- W4386244910 cites W2126244402 @default.
- W4386244910 cites W2126525177 @default.
- W4386244910 cites W2131631451 @default.
- W4386244910 cites W2131666074 @default.
- W4386244910 cites W2131717149 @default.
- W4386244910 cites W2133444149 @default.
- W4386244910 cites W2140552765 @default.
- W4386244910 cites W2150488086 @default.
- W4386244910 cites W2151698573 @default.
- W4386244910 cites W2152409376 @default.