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- W4386245825 abstract "Nicotinamide adenine dinucleotide (NAD+ ) level has been associated with various age-related diseases and its pharmacological modulation emerges as a potential approach for aging intervention. But human NAD+ landscape exhibits large heterogeneity. The lack of rapid, low-cost assays limits the establishment of whole-blood NAD+ baseline and the development of personalized therapies, especially for those with poor responses towards conventional NAD+ supplementations. Here, we developed an automated NAD+ analyzer for the rapid measurement of NAD+ with 5 μL of capillary blood using recombinant bioluminescent sensor protein and automated optical reader. The minimal invasiveness of the assay allowed a frequent and decentralized mapping of real-world NAD+ dynamics. We showed that aerobic sport and NMN supplementation increased whole-blood NAD+ and that male on average has higher NAD+ than female before the age of 50. We further revealed the long-term stability of human NAD+ baseline over 100 days and identified major real-world NAD+ -modulating behaviors." @default.
- W4386245825 created "2023-08-30" @default.
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- W4386245825 date "2023-08-28" @default.
- W4386245825 modified "2023-10-18" @default.
- W4386245825 title "Fingerstick blood assay maps real‐world <scp>NAD</scp><sup>+</sup> disparity across gender and age" @default.
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- W4386245825 doi "https://doi.org/10.1111/acel.13965" @default.
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- W4386245825 hasPublicationYear "2023" @default.
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