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- W4386250955 endingPage "19944" @default.
- W4386250955 startingPage "19932" @default.
- W4386250955 abstract "While the primary use of protein crystals has historically been in crystallographic structure determination, they have recently emerged as promising materials with many advantageous properties such as high porosity, biocompatibility, stability, structural and functional versatility, and genetic/chemical tailorability. Here, we report that the utility of protein crystals as functional materials can be further augmented through their spatial patterning and control of their morphologies. To this end, we took advantage of the chemically and kinetically controllable nature of ferritin self-assembly and constructed core–shell crystals with chemically distinct domains, tunable structural patterns, and morphologies. The spatial organization within ferritin crystals enabled the generation of patterned, multi-enzyme frameworks with cooperative catalytic behavior. We further exploited the differential growth kinetics of ferritin crystal facets to assemble Janus-type architectures with an anisotropic arrangement of chemically distinct domains. These examples represent a step toward using protein crystals as reaction vessels for complex multi-step reactions and broadening their utility as functional, solid-state materials. Our results demonstrate that morphology control and spatial patterning, which are key concepts in materials science and nanotechnology, can also be applied for engineering protein crystals." @default.
- W4386250955 created "2023-08-30" @default.
- W4386250955 creator A5038877491 @default.
- W4386250955 creator A5051768466 @default.
- W4386250955 creator A5083623372 @default.
- W4386250955 date "2023-08-29" @default.
- W4386250955 modified "2023-10-11" @default.
- W4386250955 title "Spatially Patterned, Porous Protein Crystals as Multifunctional Materials" @default.
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