Matches in SemOpenAlex for { <https://semopenalex.org/work/W4386258537> ?p ?o ?g. }
- W4386258537 endingPage "100780" @default.
- W4386258537 startingPage "100780" @default.
- W4386258537 abstract "Glioma is recognized as the most common and aggressive primary brain tumor in adults. Owing to the occurrence of drug resistance and the failure of drug to cross the blood-brain barrier (BBB), there is no effective strategy for the treatment of glioma. The main objective of this study was to develop a biomimetic glioma C6 cell membrane (C6M) derived nanovesicles (DOX-FN/C6M-NVs) loaded with doxorubicin (DOX) and ultra-small Fe nanoparticles (FN) for accomplishing the effective brain tumor-targeted delivery of DOX and improving anti-cancer efficacy via inducing collaborative apoptosis and ferroptosis. The findings revealed that employing C6M-NVs as a carrier significantly improved the therapeutic efficacy of DOX-FN/C6M-NVs by enabling evasion of immune surveillance, facilitating targeted drug delivery to tumor sites, and minimizing cardiotoxicity and adverse effects associated with DOX. DOX-FN/C6M-NVs exhibited more potent anti-tumor effects as compared with free DOX by promoting DOX-mediated apoptosis and accelerating ferroptosis via the mediation of FN. This study suggested that DOX-FN/C6M-NVs as the potential inducer of ferroptosis and apoptosis conferred effective tumor suppression in the treatment of glioma." @default.
- W4386258537 created "2023-08-30" @default.
- W4386258537 creator A5021486128 @default.
- W4386258537 creator A5033691580 @default.
- W4386258537 creator A5034679468 @default.
- W4386258537 creator A5063279291 @default.
- W4386258537 creator A5073128716 @default.
- W4386258537 creator A5074419332 @default.
- W4386258537 creator A5075995981 @default.
- W4386258537 date "2023-10-01" @default.
- W4386258537 modified "2023-10-01" @default.
- W4386258537 title "Tumor targeted cancer membrane-camouflaged ultra-small Fe nanoparticles for enhanced collaborative apoptosis and ferroptosis in glioma" @default.
- W4386258537 cites W1545715882 @default.
- W4386258537 cites W1966720603 @default.
- W4386258537 cites W1976844272 @default.
- W4386258537 cites W2011538447 @default.
- W4386258537 cites W2012610188 @default.
- W4386258537 cites W2047412618 @default.
- W4386258537 cites W2082754759 @default.
- W4386258537 cites W2102897174 @default.
- W4386258537 cites W2119972247 @default.
- W4386258537 cites W2155127143 @default.
- W4386258537 cites W2167459484 @default.
- W4386258537 cites W2340662778 @default.
- W4386258537 cites W2471383130 @default.
- W4386258537 cites W2515800095 @default.
- W4386258537 cites W2518686043 @default.
- W4386258537 cites W2790211976 @default.
- W4386258537 cites W2790408614 @default.
- W4386258537 cites W2799648066 @default.
- W4386258537 cites W2954386087 @default.
- W4386258537 cites W2981967875 @default.
- W4386258537 cites W3006431176 @default.
- W4386258537 cites W3006744532 @default.
- W4386258537 cites W3020990397 @default.
- W4386258537 cites W3022794030 @default.
- W4386258537 cites W3035752162 @default.
- W4386258537 cites W3038754858 @default.
- W4386258537 cites W3082623064 @default.
- W4386258537 cites W3092298447 @default.
- W4386258537 cites W3094037746 @default.
- W4386258537 cites W3111439440 @default.
- W4386258537 cites W3120719981 @default.
- W4386258537 cites W3151896258 @default.
- W4386258537 cites W3154124516 @default.
- W4386258537 cites W3164684473 @default.
- W4386258537 cites W3168500586 @default.
- W4386258537 cites W3170828991 @default.
- W4386258537 cites W3171178678 @default.
- W4386258537 cites W3181251993 @default.
- W4386258537 cites W3182460965 @default.
- W4386258537 cites W3191658494 @default.
- W4386258537 cites W3195938880 @default.
- W4386258537 cites W3212959806 @default.
- W4386258537 cites W3216081153 @default.
- W4386258537 cites W4200158486 @default.
- W4386258537 cites W4205154707 @default.
- W4386258537 cites W4206367141 @default.
- W4386258537 cites W4210655074 @default.
- W4386258537 cites W4223530786 @default.
- W4386258537 cites W4289525853 @default.
- W4386258537 cites W4312083612 @default.
- W4386258537 cites W4313312379 @default.
- W4386258537 cites W4366982323 @default.
- W4386258537 doi "https://doi.org/10.1016/j.mtbio.2023.100780" @default.
- W4386258537 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37680585" @default.
- W4386258537 hasPublicationYear "2023" @default.
- W4386258537 type Work @default.
- W4386258537 citedByCount "0" @default.
- W4386258537 crossrefType "journal-article" @default.
- W4386258537 hasAuthorship W4386258537A5021486128 @default.
- W4386258537 hasAuthorship W4386258537A5033691580 @default.
- W4386258537 hasAuthorship W4386258537A5034679468 @default.
- W4386258537 hasAuthorship W4386258537A5063279291 @default.
- W4386258537 hasAuthorship W4386258537A5073128716 @default.
- W4386258537 hasAuthorship W4386258537A5074419332 @default.
- W4386258537 hasAuthorship W4386258537A5075995981 @default.
- W4386258537 hasBestOaLocation W43862585371 @default.
- W4386258537 hasConcept C121608353 @default.
- W4386258537 hasConcept C126322002 @default.
- W4386258537 hasConcept C178790620 @default.
- W4386258537 hasConcept C185592680 @default.
- W4386258537 hasConcept C190283241 @default.
- W4386258537 hasConcept C2776694085 @default.
- W4386258537 hasConcept C2778227246 @default.
- W4386258537 hasConcept C2779820397 @default.
- W4386258537 hasConcept C2781303535 @default.
- W4386258537 hasConcept C31573885 @default.
- W4386258537 hasConcept C502942594 @default.
- W4386258537 hasConcept C55493867 @default.
- W4386258537 hasConcept C71924100 @default.
- W4386258537 hasConcept C96232424 @default.
- W4386258537 hasConcept C98274493 @default.
- W4386258537 hasConceptScore W4386258537C121608353 @default.
- W4386258537 hasConceptScore W4386258537C126322002 @default.
- W4386258537 hasConceptScore W4386258537C178790620 @default.
- W4386258537 hasConceptScore W4386258537C185592680 @default.
- W4386258537 hasConceptScore W4386258537C190283241 @default.