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- W4386263105 abstract "Background The cognitive impairment after percutaneous coronary intervention (PCI) in patients with acute coronary syndrome (ACS) has become a crucial clinical concern that cannot be ignored. However, studies on the early warning factors of cognitive impairment after PCI are still insufficient. Methods This study reviewed the postoperative cognitive function of 284 patients who underwent PCI in our hospital from June 2019 to June 2022. During the 21-day follow-up, all participants included in the analysis were divided into the cognitive impairment (CI) group ( n = 82) and the noncognitive impairment (NCI) group ( n = 186) according to their Montreal cognitive assessment (MoCA) scale. Participants’ serum 25(OH)D 3 levels on admission and serum neuron-specific enolase (NSE), glial fibrillary acidic protein (GFAP) and S100β levels were measured 21 days after surgery. Results Age more than 65 years, hypertension, operation time longer than 60 min, left ventricular ejection fraction less than 50% and serum 25(OH)D 3 less than 31.41 ng/ml were the risk factors for cognitive dysfunction in ACS patients 21 days after PCI. Serum levels of 25(OH)D 3 , NSE, S100β and GFAP were significantly higher in patients with cognitive impairment than in patients without cognitive impairment. Conclusion Postoperative serum NSE, S100β and GFAP levels were significantly negatively correlated with serum 25(OH)D 3 levels at admission. The serum 25(OH)D 3 level is a risk factor and predictor of cognitive impairment in patients with ACS after PCI." @default.
- W4386263105 created "2023-08-30" @default.
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- W4386263105 date "2023-10-01" @default.
- W4386263105 modified "2023-09-27" @default.
- W4386263105 title "Serum levels of 25-OH vitamin D levels predict cognitive impairments among acute coronary syndrome patients" @default.
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- W4386263105 doi "https://doi.org/10.2459/jcm.0000000000001542" @default.
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