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- W4386280151 abstract "The main brake for the success of assisted reproductive treatments remains the still low implantation rate of transferred embryos described by R. G. Edwards as “the last barrier” in reproductive medicine. Only 15 to 20% of day-3 embryos and 30% of day-5 embryos will effectively lead to a birth. In humans, indeed, most pregnancy losses occur before or during embryo implantation. The endometrial immune profiling was developed in 2012 to analyze the local immune reaction occurring in the endometrium at the time of the implantation window. The main hypothesis is that some failures (despite the production of good quality embryos) could be the consequence of uterine immune dysregulations, which could be anticipated and corrected with personalized therapies. During the presentation, we will go back over the steps of research in animal model (which we owe to Gerard Chaouat) that allowed us to consider a human translational approach. Then we will detail the steps necessary to bring an idea to an application available for patients. The immune profiling is based on RT-qPCR analysis of CD56 uNK levels, IL-15/Fn-14 ratios (Interleukin-15/Fibroblast growth factor-inducible molecule) and IL-18/TWEAK ratios (Interleukin-18/Tumor necrosis factor-like weak inducer of apoptosis), all factors known to be intimately involved in the differentiation of the secretory endometrium toward the receptive state. By documenting the local immune response expected during the period of uterine receptivity, we seek to detect imbalances which can be corrected to promote further embryo implantation. Results in large prospective cohorts, controlled cohort study, interim results and pitfalls of the randomized controlled trial will be presented. These results suggest that patients with an history of repeated implantation failures or recurrent miscarriages highly benefit from a personalized management with a very significant increase of subsequent live birth rate if a deregulation is diagnosed and corrected." @default.
- W4386280151 created "2023-08-31" @default.
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- W4386280151 date "2023-08-01" @default.
- W4386280151 modified "2023-10-15" @default.
- W4386280151 title "15:00-15:20 The Endometrial Immune Profiling: Where are we after 10 years?" @default.
- W4386280151 doi "https://doi.org/10.1016/j.jri.2022.103574" @default.
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