FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4386282469> ?p ?o ?g. }

• W4386282469 abstract "Abstract MR1 is a ubiquitously expressed MHC-Ib molecule that presents microbial metabolites to MR1-restricted T cells, but there are differences in the antigen presentation pathway of an intracellular microbe compared to exogenous antigen. We have shown the importance of endosomal trafficking proteins in MR1-dependent presentation of Mycobacterium tuberculosis (Mtb). Two pore channels (TPCs) are endosomal calcium channels that regulate endosomal trafficking. Due to their location on endosomes, we hypothesized that TPCs could be required for MR1-dependent presentation of antigens derived from the intracellular microbe Mtb. We found that TPCs are critical for the presentation of Mtb by MR1; inhibition of TPCs had no effect on MR1 presentation of extracellular (exogenous) antigens, HLA-B presentation, or HLA-II presentation. Finally, we found that the calcium sensitive trafficking protein Synaptotagmin 7 was also key in the presentation of Mtb by MR1. This calcium-dependent endosomal pathway is a novel mechanism by which the immune system can sample intracellular antigens." @default.
• W4386282469 created "2023-08-31" @default.
• W4386282469 creator A5024123838 @default.
• W4386282469 creator A5030668277 @default.
• W4386282469 creator A5032119661 @default.
• W4386282469 creator A5047907612 @default.
• W4386282469 creator A5085629509 @default.
• W4386282469 creator A5092717209 @default.
• W4386282469 date "2023-08-30" @default.
• W4386282469 modified "2023-10-03" @default.
• W4386282469 title "Calcium Signaling in MR1-Dependent Antigen Presentation of Mycobacterium tuberculosis." @default.
• W4386282469 cites W1967808562 @default.
• W4386282469 cites W2007066406 @default.
• W4386282469 cites W2008617601 @default.
• W4386282469 cites W2031790758 @default.
• W4386282469 cites W2031854861 @default.
• W4386282469 cites W2033232488 @default.
• W4386282469 cites W2043620814 @default.
• W4386282469 cites W2062307034 @default.
• W4386282469 cites W2065252029 @default.
• W4386282469 cites W2067327881 @default.
• W4386282469 cites W2073247934 @default.
• W4386282469 cites W2108594642 @default.
• W4386282469 cites W2115072914 @default.
• W4386282469 cites W2124376809 @default.
• W4386282469 cites W2127463580 @default.
• W4386282469 cites W2139632459 @default.
• W4386282469 cites W2162709457 @default.
• W4386282469 cites W2323955433 @default.
• W4386282469 cites W2327739049 @default.
• W4386282469 cites W2513049377 @default.
• W4386282469 cites W2588744007 @default.
• W4386282469 cites W2746127582 @default.
• W4386282469 cites W2883450285 @default.
• W4386282469 cites W2908770791 @default.
• W4386282469 cites W2921896742 @default.
• W4386282469 cites W2999041150 @default.
• W4386282469 cites W3033539155 @default.
• W4386282469 cites W3042551908 @default.
• W4386282469 cites W3087215755 @default.
• W4386282469 cites W3110572899 @default.
• W4386282469 cites W4286750382 @default.
• W4386282469 cites W4295066887 @default.
• W4386282469 doi "https://doi.org/10.21203/rs.3.rs-3154465/v1" @default.
• W4386282469 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37693580" @default.
• W4386282469 hasPublicationYear "2023" @default.
• W4386282469 type Work @default.
• W4386282469 citedByCount "0" @default.
• W4386282469 crossrefType "posted-content" @default.
• W4386282469 hasAuthorship W4386282469A5024123838 @default.
• W4386282469 hasAuthorship W4386282469A5030668277 @default.
• W4386282469 hasAuthorship W4386282469A5032119661 @default.
• W4386282469 hasAuthorship W4386282469A5047907612 @default.
• W4386282469 hasAuthorship W4386282469A5085629509 @default.
• W4386282469 hasAuthorship W4386282469A5092717209 @default.
• W4386282469 hasBestOaLocation W43862824691 @default.
• W4386282469 hasConcept C102747710 @default.
• W4386282469 hasConcept C108249834 @default.
• W4386282469 hasConcept C142724271 @default.
• W4386282469 hasConcept C147483822 @default.
• W4386282469 hasConcept C185592680 @default.
• W4386282469 hasConcept C203014093 @default.
• W4386282469 hasConcept C2776090121 @default.
• W4386282469 hasConcept C2777975735 @default.
• W4386282469 hasConcept C2778973524 @default.
• W4386282469 hasConcept C2781069245 @default.
• W4386282469 hasConcept C28406088 @default.
• W4386282469 hasConcept C71924100 @default.
• W4386282469 hasConcept C79879829 @default.
• W4386282469 hasConcept C83464605 @default.
• W4386282469 hasConcept C86803240 @default.
• W4386282469 hasConcept C8891405 @default.
• W4386282469 hasConcept C95444343 @default.
• W4386282469 hasConceptScore W4386282469C102747710 @default.
• W4386282469 hasConceptScore W4386282469C108249834 @default.
• W4386282469 hasConceptScore W4386282469C142724271 @default.
• W4386282469 hasConceptScore W4386282469C147483822 @default.
• W4386282469 hasConceptScore W4386282469C185592680 @default.
• W4386282469 hasConceptScore W4386282469C203014093 @default.
• W4386282469 hasConceptScore W4386282469C2776090121 @default.
• W4386282469 hasConceptScore W4386282469C2777975735 @default.
• W4386282469 hasConceptScore W4386282469C2778973524 @default.
• W4386282469 hasConceptScore W4386282469C2781069245 @default.
• W4386282469 hasConceptScore W4386282469C28406088 @default.
• W4386282469 hasConceptScore W4386282469C71924100 @default.
• W4386282469 hasConceptScore W4386282469C79879829 @default.
• W4386282469 hasConceptScore W4386282469C83464605 @default.
• W4386282469 hasConceptScore W4386282469C86803240 @default.
• W4386282469 hasConceptScore W4386282469C8891405 @default.
• W4386282469 hasConceptScore W4386282469C95444343 @default.
• W4386282469 hasLocation W43862824691 @default.
• W4386282469 hasLocation W43862824692 @default.
• W4386282469 hasOpenAccess W4386282469 @default.
• W4386282469 hasPrimaryLocation W43862824691 @default.
• W4386282469 hasRelatedWork W1980812273 @default.
• W4386282469 hasRelatedWork W2006325825 @default.
• W4386282469 hasRelatedWork W2008470504 @default.
• W4386282469 hasRelatedWork W2067551077 @default.
• W4386282469 hasRelatedWork W2156596722 @default.
• W4386282469 hasRelatedWork W2160605889 @default.

• next