FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4386284481> ?p ?o ?g. }

• W4386284481 endingPage "13459" @default.
• W4386284481 startingPage "13459" @default.
• W4386284481 abstract "Depression is a global mental health concern, and personalized treatment approaches are needed to optimize its management. This study aimed to investigate the influence of the CYP2D6 and CYP1A2 gene polymorphisms on the efficacy of duloxetine in reducing depressive and anxiety symptoms. A sample of 100 outpatients with major depression, who initiated monotherapy with duloxetine, were followed up. Polymorphisms in the CYP2D6 and CYP1A2 genes were assessed. The severity of depressive and anxiety symptoms was recorded using standardized scales. Adverse drug reactions (ADRs) were analyzed. Statistical analyses, including linear regression, were conducted to examine the relationships between genetic polymorphisms, clinical variables, and treatment outcomes. Patients with higher values of the duloxetine metabolic index (DMI) for CYP2D6, indicating a faster metabolism, achieved a greater reduction in anxiety symptoms. The occurrence of ADRs was associated with a lower reduction in anxiety symptoms. However, no significant associations were found between studied gene polymorphisms and reduction in depressive symptoms. No significant effects of the DMI for CYP1A2 were found. Patients with a slower metabolism may experience less benefit from duloxetine therapy in terms of anxiety symptom reduction. Personalizing treatment based on the CYP2D6 and CYP1A2 gene polymorphisms can enhance the effectiveness of antidepressant therapy and improve patient outcomes." @default.
• W4386284481 created "2023-08-31" @default.
• W4386284481 creator A5001681521 @default.
• W4386284481 creator A5025181350 @default.
• W4386284481 creator A5026756876 @default.
• W4386284481 creator A5038755811 @default.
• W4386284481 creator A5065383218 @default.
• W4386284481 creator A5078845068 @default.
• W4386284481 date "2023-08-30" @default.
• W4386284481 modified "2023-10-02" @default.
• W4386284481 title "The Impact of the CYP2D6 and CYP1A2 Gene Polymorphisms on Response to Duloxetine in Patients with Major Depression" @default.
• W4386284481 cites W1004452157 @default.
• W4386284481 cites W1543737679 @default.
• W4386284481 cites W1630545408 @default.
• W4386284481 cites W1985244478 @default.
• W4386284481 cites W1991071998 @default.
• W4386284481 cites W1991756274 @default.
• W4386284481 cites W1994256806 @default.
• W4386284481 cites W2002050650 @default.
• W4386284481 cites W2012723101 @default.
• W4386284481 cites W2016577926 @default.
• W4386284481 cites W2032531780 @default.
• W4386284481 cites W2054739757 @default.
• W4386284481 cites W2063373801 @default.
• W4386284481 cites W2069090735 @default.
• W4386284481 cites W2070828096 @default.
• W4386284481 cites W2089348163 @default.
• W4386284481 cites W2114824785 @default.
• W4386284481 cites W2137228215 @default.
• W4386284481 cites W2152797524 @default.
• W4386284481 cites W2160070901 @default.
• W4386284481 cites W2168481476 @default.
• W4386284481 cites W2225684373 @default.
• W4386284481 cites W2330871695 @default.
• W4386284481 cites W2337732073 @default.
• W4386284481 cites W2613757334 @default.
• W4386284481 cites W2804934735 @default.
• W4386284481 cites W3047546857 @default.
• W4386284481 cites W3093747537 @default.
• W4386284481 cites W3160285015 @default.
• W4386284481 cites W4214699779 @default.
• W4386284481 cites W4380991535 @default.
• W4386284481 doi "https://doi.org/10.3390/ijms241713459" @default.
• W4386284481 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37686266" @default.
• W4386284481 hasPublicationYear "2023" @default.
• W4386284481 type Work @default.
• W4386284481 citedByCount "0" @default.
• W4386284481 crossrefType "journal-article" @default.
• W4386284481 hasAuthorship W4386284481A5001681521 @default.
• W4386284481 hasAuthorship W4386284481A5025181350 @default.
• W4386284481 hasAuthorship W4386284481A5026756876 @default.
• W4386284481 hasAuthorship W4386284481A5038755811 @default.
• W4386284481 hasAuthorship W4386284481A5065383218 @default.
• W4386284481 hasAuthorship W4386284481A5078845068 @default.
• W4386284481 hasBestOaLocation W43862844811 @default.
• W4386284481 hasConcept C104317684 @default.
• W4386284481 hasConcept C118552586 @default.
• W4386284481 hasConcept C126322002 @default.
• W4386284481 hasConcept C135763542 @default.
• W4386284481 hasConcept C139719470 @default.
• W4386284481 hasConcept C142724271 @default.
• W4386284481 hasConcept C15744967 @default.
• W4386284481 hasConcept C162324750 @default.
• W4386284481 hasConcept C204787440 @default.
• W4386284481 hasConcept C2776867660 @default.
• W4386284481 hasConcept C2779177272 @default.
• W4386284481 hasConcept C2780764818 @default.
• W4386284481 hasConcept C33664856 @default.
• W4386284481 hasConcept C526171541 @default.
• W4386284481 hasConcept C54355233 @default.
• W4386284481 hasConcept C55775858 @default.
• W4386284481 hasConcept C558461103 @default.
• W4386284481 hasConcept C62231903 @default.
• W4386284481 hasConcept C71924100 @default.
• W4386284481 hasConcept C86745063 @default.
• W4386284481 hasConcept C86803240 @default.
• W4386284481 hasConcept C98274493 @default.
• W4386284481 hasConceptScore W4386284481C104317684 @default.
• W4386284481 hasConceptScore W4386284481C118552586 @default.
• W4386284481 hasConceptScore W4386284481C126322002 @default.
• W4386284481 hasConceptScore W4386284481C135763542 @default.
• W4386284481 hasConceptScore W4386284481C139719470 @default.
• W4386284481 hasConceptScore W4386284481C142724271 @default.
• W4386284481 hasConceptScore W4386284481C15744967 @default.
• W4386284481 hasConceptScore W4386284481C162324750 @default.
• W4386284481 hasConceptScore W4386284481C204787440 @default.
• W4386284481 hasConceptScore W4386284481C2776867660 @default.
• W4386284481 hasConceptScore W4386284481C2779177272 @default.
• W4386284481 hasConceptScore W4386284481C2780764818 @default.
• W4386284481 hasConceptScore W4386284481C33664856 @default.
• W4386284481 hasConceptScore W4386284481C526171541 @default.
• W4386284481 hasConceptScore W4386284481C54355233 @default.
• W4386284481 hasConceptScore W4386284481C55775858 @default.
• W4386284481 hasConceptScore W4386284481C558461103 @default.
• W4386284481 hasConceptScore W4386284481C62231903 @default.
• W4386284481 hasConceptScore W4386284481C71924100 @default.
• W4386284481 hasConceptScore W4386284481C86745063 @default.
• W4386284481 hasConceptScore W4386284481C86803240 @default.

• next