Matches in SemOpenAlex for { <https://semopenalex.org/work/W4386285520> ?p ?o ?g. }
- W4386285520 abstract "Abstract Amyotrophic lateral sclerosis (ALS) is the most prevalent and lethal class of severe motor neuron diseases (MND) with no efficacious treatment. The pathogenic mechanisms underlying ALS remain unclear. Nearly 90% of patients exhibit sporadic onset (sALS). Therefore, elucidating the pathophysiology of ALS is imperative. Long non-coding RNA (lncRNA) is a large class of non-coding RNAs that regulate transcription, translation and post-translational processes. LncRNAs contribute to the pathogenesis of diverse neurodegenerative disorders and hold promise as targets for interference in the realm of neurodegeneration. However, the mechanisms of which lncRNAs are involved in ALS have not been thoroughly investigated. We identified and validated a downregulated lncRNA, lnc-HIBADH-4, in ALS which correlated with disease severity and overall survival. Lnc-HIBADH-4 acted as a molecular sponge regulating lysosomal function through the lnc-HIBADH-4/miR-326/CTSD pathway, thereby impacting autophagy-lysosome dynamics and the levels of cell proliferation and apoptosis. Therefore, this study discovered and revealed the role of lnc-HIBADH-4 in the pathogenesis of ALS. With further research, lnc-HIBADH-4 is expected to provide a new biomarker in the diagnosis and treatment of ALS." @default.
- W4386285520 created "2023-08-31" @default.
- W4386285520 creator A5007009539 @default.
- W4386285520 creator A5011891513 @default.
- W4386285520 creator A5028688827 @default.
- W4386285520 creator A5039872049 @default.
- W4386285520 creator A5045669688 @default.
- W4386285520 creator A5048512835 @default.
- W4386285520 creator A5062691277 @default.
- W4386285520 creator A5064615194 @default.
- W4386285520 creator A5080297327 @default.
- W4386285520 date "2023-08-30" @default.
- W4386285520 modified "2023-10-18" @default.
- W4386285520 title "Lnc-HIBADH-4 regulates autophagy-lysosome pathway in amyotrophic lateral sclerosis by targeting Cathepsin D" @default.
- W4386285520 cites W2009266531 @default.
- W4386285520 cites W2022649483 @default.
- W4386285520 cites W2032183472 @default.
- W4386285520 cites W2034283361 @default.
- W4386285520 cites W2046250764 @default.
- W4386285520 cites W2055897605 @default.
- W4386285520 cites W2064891909 @default.
- W4386285520 cites W2087377443 @default.
- W4386285520 cites W2112538318 @default.
- W4386285520 cites W2114872355 @default.
- W4386285520 cites W2119141725 @default.
- W4386285520 cites W2121981334 @default.
- W4386285520 cites W2130687298 @default.
- W4386285520 cites W2171660564 @default.
- W4386285520 cites W2286637061 @default.
- W4386285520 cites W2297831727 @default.
- W4386285520 cites W2502698579 @default.
- W4386285520 cites W2510868781 @default.
- W4386285520 cites W2563538576 @default.
- W4386285520 cites W2619434486 @default.
- W4386285520 cites W2748137738 @default.
- W4386285520 cites W2784570320 @default.
- W4386285520 cites W2795848004 @default.
- W4386285520 cites W2806572652 @default.
- W4386285520 cites W2887505504 @default.
- W4386285520 cites W2944010334 @default.
- W4386285520 cites W2954465031 @default.
- W4386285520 cites W2990564597 @default.
- W4386285520 cites W2998324388 @default.
- W4386285520 cites W3017118036 @default.
- W4386285520 cites W3027145092 @default.
- W4386285520 cites W3036212008 @default.
- W4386285520 cites W3041849832 @default.
- W4386285520 cites W3041917243 @default.
- W4386285520 cites W3160385421 @default.
- W4386285520 cites W3164735937 @default.
- W4386285520 cites W3171124897 @default.
- W4386285520 cites W3185034576 @default.
- W4386285520 cites W3196453577 @default.
- W4386285520 cites W3198750604 @default.
- W4386285520 cites W3208849487 @default.
- W4386285520 cites W4200287522 @default.
- W4386285520 cites W4210998205 @default.
- W4386285520 cites W4214524475 @default.
- W4386285520 cites W4226193258 @default.
- W4386285520 cites W4281616414 @default.
- W4386285520 cites W4283367225 @default.
- W4386285520 cites W4292707766 @default.
- W4386285520 cites W4319333100 @default.
- W4386285520 cites W4319970282 @default.
- W4386285520 doi "https://doi.org/10.21203/rs.3.rs-3293395/v1" @default.
- W4386285520 hasPublicationYear "2023" @default.
- W4386285520 type Work @default.
- W4386285520 citedByCount "0" @default.
- W4386285520 crossrefType "posted-content" @default.
- W4386285520 hasAuthorship W4386285520A5007009539 @default.
- W4386285520 hasAuthorship W4386285520A5011891513 @default.
- W4386285520 hasAuthorship W4386285520A5028688827 @default.
- W4386285520 hasAuthorship W4386285520A5039872049 @default.
- W4386285520 hasAuthorship W4386285520A5045669688 @default.
- W4386285520 hasAuthorship W4386285520A5048512835 @default.
- W4386285520 hasAuthorship W4386285520A5062691277 @default.
- W4386285520 hasAuthorship W4386285520A5064615194 @default.
- W4386285520 hasAuthorship W4386285520A5080297327 @default.
- W4386285520 hasBestOaLocation W43862855201 @default.
- W4386285520 hasConcept C142724271 @default.
- W4386285520 hasConcept C169760540 @default.
- W4386285520 hasConcept C181199279 @default.
- W4386285520 hasConcept C190283241 @default.
- W4386285520 hasConcept C203014093 @default.
- W4386285520 hasConcept C203522944 @default.
- W4386285520 hasConcept C2776925932 @default.
- W4386285520 hasConcept C2779134260 @default.
- W4386285520 hasConcept C2780216420 @default.
- W4386285520 hasConcept C2780596555 @default.
- W4386285520 hasConcept C2780942790 @default.
- W4386285520 hasConcept C54355233 @default.
- W4386285520 hasConcept C55493867 @default.
- W4386285520 hasConcept C71924100 @default.
- W4386285520 hasConcept C86803240 @default.
- W4386285520 hasConcept C95444343 @default.
- W4386285520 hasConceptScore W4386285520C142724271 @default.
- W4386285520 hasConceptScore W4386285520C169760540 @default.
- W4386285520 hasConceptScore W4386285520C181199279 @default.
- W4386285520 hasConceptScore W4386285520C190283241 @default.
- W4386285520 hasConceptScore W4386285520C203014093 @default.