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• W4386296105 endingPage "194981" @default.
• W4386296105 startingPage "194981" @default.
• W4386296105 abstract "SAGA (Spt-Ada-Gcn5-Acetyltransferase), an evolutionarily conserved transcriptional co-activator among eukaryotes, is a large multi-subunit protein complex with two distinct enzymatic activities, namely HAT (Histone acetyltransferase) and DUB (De-ubiquitinase), and is targeted to the promoter by the gene-specific activator proteins for histone covalent modifications and PIC (Pre-initiation complex) formation in enhancing transcription (or gene activation). Targeting of SAGA to the gene promoter is further facilitated by the 19S RP (Regulatory particle) of the 26S proteasome (that is involved in targeted degradation of protein via ubiquitylation) in a proteolysis-independent manner. Moreover, SAGA is also recently found to be regulated by the 26S proteasome in a proteolysis-dependent manner via the ubiquitylation of its Sgf73/ataxin-7 component that is required for SAGA's integrity and DUB activity (and hence transcription), and is linked to various diseases including neurodegenerative disorders and cancer. Thus, SAGA itself and its targeting to the active gene are regulated by the UPS (Ubiquitin-proteasome system) with implications in diseases." @default.
• W4386296105 created "2023-08-31" @default.
• W4386296105 creator A5014284886 @default.
• W4386296105 creator A5022594647 @default.
• W4386296105 creator A5084946819 @default.
• W4386296105 creator A5092719420 @default.
• W4386296105 date "2023-12-01" @default.
• W4386296105 modified "2023-09-30" @default.
• W4386296105 title "UPS writes a new saga of SAGA" @default.
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