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• W4386299114 abstract "Epilepsy is the major cause of morbidity and mortality despite the availability of varied drugs. The current antiepileptic drugs (AEDs), however, solve numerous problems, but still many adverse reactions are observed in patients for instance; enzyme induction; impact of these drugs on growth and bone metabolism; effect on visual performance, etc. Along with this, the drug resistance epilepsy still remains a problem. Most of the antiepileptic therapies focus on combined administration of two or more AEDs, but this is still not the solution to existing complications. These facts dictate a clear-cut need of a novel, third-generation, safe, and effective AED. The safety and efficacy of herbal drugs in treatment of various ailments including epilepsy have been supported by a vast literature published time to time. The phyto-constituents present in these herbal sources, e.g., Bacopa monnierie, Acanthus montanus, Alchornea laxiflora, Berberine, and many others, were found to act potentially on AED targets, which are voltage-gated Ca2+ channel, voltage-gated K+ channels (A- or M-type), voltage-gated sodium channel, GABAA receptors, Nicotinic cholinergic receptors, Glycine receptor, NMDA receptor, AMPA receptor, and ionotropic glutamate receptors, etc. Thus, we have a large database of phyto-constituents, which are effective against various types of epilepsies; and through a systematic approach involving structure–activity relationship study, computational approach such as molecular docking and pharmacophore modeling, new and safer AED can be developed. Along with the pharmacological therapy of Epilepsy and problems associated with the use of AEDs, this chapter includes the antiepileptic activity of various herbal drugs available through literarure. Those phyto-constituents which are responsible for anti epileptic activity, can serve as possible leads for the development of new, safer third-generation antiepileptic drugs." @default.
• W4386299114 created "2023-08-31" @default.
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• W4386299114 date "2023-01-01" @default.
• W4386299114 modified "2023-10-01" @default.
• W4386299114 title "Phyto-Constituents as Potential Leads for the Development of Novel Antiepileptic Drugs" @default.
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• W4386299114 doi "https://doi.org/10.1007/978-3-031-28780-0_34" @default.
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