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- W4386305736 abstract "Osteosarcoma (OS) is the most common primary malignant bone tumor that more commonly occurs in children and adolescents. The most commonly used treatment for OS is surgery combined with chemotherapy, but the treatment outcomes are typically unsatisfactory. High rates of metastasis and post-treatment recurrence rates are major challenges in the treatment of OS. This underlines the need for studying the in-depth characterization of the pathogenetic mechanisms of OS and development of more effective therapeutic modalities. Previous studies have demonstrated the important role of the bone microenvironment and the regulation of signaling pathways in the occurrence and development of OS. In this review, we discussed the available evidence pertaining to the mechanisms of OS development and identified therapeutic targets for OS. We also summarized the available treatment modalities for OS and identified future priorities for therapeutics research." @default.
- W4386305736 created "2023-09-01" @default.
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- W4386305736 date "2023-08-31" @default.
- W4386305736 modified "2023-09-27" @default.
- W4386305736 title "Research progress in the mechanism and treatment of osteosarcoma" @default.
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- W4386305736 doi "https://doi.org/10.1097/cm9.0000000000002800" @default.
- W4386305736 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37649421" @default.
- W4386305736 hasPublicationYear "2023" @default.
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