FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4386305810> ?p ?o ?g. }

• W4386305810 abstract "The present study examines differences in metabolic and pancreatic islet adaptative responses following streptozotocin (STZ) and hydrocortisone (HC) administration in male and female transgenic GluCreERT2/Rosa26-eYFP mice. Mice received five daily doses of STZ (50 mg/kg, i.p.) or 10 daily doses of HC (70 mg/kg, i.p.), with parameters assessed on day 11. STZ-induced hyperglycaemia was evident in both sexes, alongside impaired glucose tolerance and reduced insulin concentrations. HC also had similar metabolic effects in male and female mice resulting in classical increases of circulating insulin indicative of insulin resistance. Control male mice had larger pancreatic islets than females and displayed a greater reduction of islet and beta-cell area in response to STZ insult. In addition, female STZ mice had lower levels of beta-cell apoptosis than male counterparts. Following HC administration, female mouse islets contained a greater proportion of alpha cells when compared to males. All HC mice presented with relatively comparable increases in beta- and alpha-cell turnover rates, with female mice being slightly more susceptible to HC-induced beta-cell apoptosis. Interestingly, healthy control female mice had inherently increased alpha-to-beta-cell transdifferentiation rates, which was decreased by HC treatment. The number of glucagon-positive alpha cells altering their lineage to insulin-positive beta cells was increased in male, but not female, STZ mice. Taken together, although there was no obvious sex-specific alteration of metabolic profile in STZ or HC mice, subtle differences in pancreatic islet morphology emphasises the impact of sex hormones on islets and importance of taking care when interpreting observations between males and females." @default.
• W4386305810 created "2023-09-01" @default.
• W4386305810 creator A5001545372 @default.
• W4386305810 creator A5025115590 @default.
• W4386305810 creator A5060340257 @default.
• W4386305810 creator A5061926350 @default.
• W4386305810 creator A5075620817 @default.
• W4386305810 creator A5079594961 @default.
• W4386305810 creator A5092721422 @default.
• W4386305810 date "2023-08-31" @default.
• W4386305810 modified "2023-10-12" @default.
• W4386305810 title "Sex-based impact of pancreatic islet stressors in GluCreERT2/Rosa26-eYFP mice" @default.
• W4386305810 cites W1868158647 @default.
• W4386305810 cites W1966199649 @default.
• W4386305810 cites W1968285615 @default.
• W4386305810 cites W1984170856 @default.
• W4386305810 cites W1986519087 @default.
• W4386305810 cites W2006404588 @default.
• W4386305810 cites W2037621705 @default.
• W4386305810 cites W2039787693 @default.
• W4386305810 cites W2049434572 @default.
• W4386305810 cites W2051214933 @default.
• W4386305810 cites W2054156175 @default.
• W4386305810 cites W2077229049 @default.
• W4386305810 cites W2088012387 @default.
• W4386305810 cites W2135491929 @default.
• W4386305810 cites W2136317511 @default.
• W4386305810 cites W2152445765 @default.
• W4386305810 cites W2155881904 @default.
• W4386305810 cites W2157632524 @default.
• W4386305810 cites W2159678191 @default.
• W4386305810 cites W2171650768 @default.
• W4386305810 cites W2177887995 @default.
• W4386305810 cites W2335428428 @default.
• W4386305810 cites W2415422374 @default.
• W4386305810 cites W2489171943 @default.
• W4386305810 cites W2750085463 @default.
• W4386305810 cites W2790481421 @default.
• W4386305810 cites W2792524495 @default.
• W4386305810 cites W2806507802 @default.
• W4386305810 cites W2810082108 @default.
• W4386305810 cites W2895707238 @default.
• W4386305810 cites W2913465969 @default.
• W4386305810 cites W2945569191 @default.
• W4386305810 cites W2953226492 @default.
• W4386305810 cites W2954561682 @default.
• W4386305810 cites W3002253725 @default.
• W4386305810 cites W3006492268 @default.
• W4386305810 cites W3006783444 @default.
• W4386305810 cites W3009202307 @default.
• W4386305810 cites W3024506005 @default.
• W4386305810 cites W3033773215 @default.
• W4386305810 cites W3037425074 @default.
• W4386305810 cites W3040167468 @default.
• W4386305810 cites W3081234002 @default.
• W4386305810 cites W3083963077 @default.
• W4386305810 cites W3134065768 @default.
• W4386305810 cites W3166005657 @default.
• W4386305810 cites W3176792914 @default.
• W4386305810 cites W3204635668 @default.
• W4386305810 cites W4200449779 @default.
• W4386305810 cites W4213166407 @default.
• W4386305810 cites W4251179846 @default.
• W4386305810 cites W4280531940 @default.
• W4386305810 cites W4295539332 @default.
• W4386305810 cites W4323664834 @default.
• W4386305810 cites W4323804403 @default.
• W4386305810 cites W4366277387 @default.
• W4386305810 cites W4367320330 @default.
• W4386305810 doi "https://doi.org/10.1530/joe-23-0174" @default.
• W4386305810 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37650517" @default.
• W4386305810 hasPublicationYear "2023" @default.
• W4386305810 type Work @default.
• W4386305810 citedByCount "0" @default.
• W4386305810 crossrefType "journal-article" @default.
• W4386305810 hasAuthorship W4386305810A5001545372 @default.
• W4386305810 hasAuthorship W4386305810A5025115590 @default.
• W4386305810 hasAuthorship W4386305810A5060340257 @default.
• W4386305810 hasAuthorship W4386305810A5061926350 @default.
• W4386305810 hasAuthorship W4386305810A5075620817 @default.
• W4386305810 hasAuthorship W4386305810A5079594961 @default.
• W4386305810 hasAuthorship W4386305810A5092721422 @default.
• W4386305810 hasBestOaLocation W43863058101 @default.
• W4386305810 hasConcept C126322002 @default.
• W4386305810 hasConcept C134018914 @default.
• W4386305810 hasConcept C1491633281 @default.
• W4386305810 hasConcept C165220095 @default.
• W4386305810 hasConcept C199360897 @default.
• W4386305810 hasConcept C2776174256 @default.
• W4386305810 hasConcept C2776828364 @default.
• W4386305810 hasConcept C2777300450 @default.
• W4386305810 hasConcept C2778563252 @default.
• W4386305810 hasConcept C2779280383 @default.
• W4386305810 hasConcept C2779306644 @default.
• W4386305810 hasConcept C2779855799 @default.
• W4386305810 hasConcept C41008148 @default.
• W4386305810 hasConcept C54355233 @default.
• W4386305810 hasConcept C555293320 @default.
• W4386305810 hasConcept C60870556 @default.
• W4386305810 hasConcept C71315377 @default.

• next