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- W4386305813 abstract "Cancer is the world's second leading cause of mortality and one of the major public health problems. Cancer incidence and mortality rates remain high despite the great advancements in existing therapeutic, diagnostic, and preventive approaches. Therefore, a quest for less toxic and more efficient anti-cancer strategies is still at the forefront of the current research. Traditionally important, curcumin commonly known as a wonder molecule has received considerable attention as an anti-cancer, anti-inflammatory, and antioxidant candidate. However, limited water solubility and low bioavailability restrict its extensive utility in different pathological states. The investigators are making consistent efforts to develop newer strategies to overcome its limitations by designing different analogues with better pharmacokinetic and pharmacodynamic properties. The present review highlights the recent updates on curcumin and its analogues with special emphasis on various mechanistic pathways involved in anti-cancer activity. In addition, the structure-activity relationship of curcumin analogues has also been precisely discussed. This article will also provide key information for the design and development of newer curcumin analogues with desired pharmacokinetic and pharmacodynamic profiles and will provide in depth understanding of molecular pathways involved in the anti-cancer activities." @default.
- W4386305813 created "2023-09-01" @default.
- W4386305813 creator A5020048229 @default.
- W4386305813 creator A5049040344 @default.
- W4386305813 creator A5068516467 @default.
- W4386305813 creator A5080121702 @default.
- W4386305813 creator A5080341754 @default.
- W4386305813 date "2023-08-30" @default.
- W4386305813 modified "2023-09-27" @default.
- W4386305813 title "Mechanism insights of curcumin and its analogues in cancer: An update" @default.
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